Aims: to compare inflammation markers and MMPs in nondiabetic and diabetic subjects during OGTT Methods: we enrolled 256 nondiabetic subjects (M/F: 132/124; age: 46±4) and 274 type 2 diabetic subjects (M/F: 134/140; age: 48±5), wellcontrolled (HbA1c < 7.0%) with diet and physical activity. We underwent an OGTT (3 hours) and we measured sICAM-1, IL-6, CRP, sVCAM-1, sE-selectin, TNF-alpha, adiponectin, Nitrites/Nitrates, MMP-2, and MMP-9 at time 0, 30, 60, 90, 120, and 180 min. Results: no patients reported side effects during OGTT; at baseline and after 180 min., sICAM-1, IL-6, sE-selectin, TNF-alpha, and MMPs were significantly higher (p< 0.05) in diabetic compared to nondiabetic subjects, while CRP, and sVCAM-1 were significantly higher (p< 0.01) in diabetic compared to nondiabetic subjects. Adiponectin, and Nitrites/Nitrates were significantly lower (p< 0.01) in diabetic compared to nondiabetic subjects. Conclusions: the examined inflammation markers and MMPs are modified in diabetic compared to non diabetic subjects in fasting state and after OGTT.
Derosa, G., Cicero, A., D'Angelo, A., Celentano, C., Fiorenza, A.M., Salvadeo, S., et al. (2007). Inflammation markers and MMPS in nondiabetic and diabetic subjects OGTT. ATHEROSCLEROSIS SUPPLEMENTS, 8(1), 66-67 [10.1016/S1567-5688(07)71210-2].
Inflammation markers and MMPS in nondiabetic and diabetic subjects OGTT
Cicero, AFGSecondo
Writing – Original Draft Preparation
;
2007
Abstract
Aims: to compare inflammation markers and MMPs in nondiabetic and diabetic subjects during OGTT Methods: we enrolled 256 nondiabetic subjects (M/F: 132/124; age: 46±4) and 274 type 2 diabetic subjects (M/F: 134/140; age: 48±5), wellcontrolled (HbA1c < 7.0%) with diet and physical activity. We underwent an OGTT (3 hours) and we measured sICAM-1, IL-6, CRP, sVCAM-1, sE-selectin, TNF-alpha, adiponectin, Nitrites/Nitrates, MMP-2, and MMP-9 at time 0, 30, 60, 90, 120, and 180 min. Results: no patients reported side effects during OGTT; at baseline and after 180 min., sICAM-1, IL-6, sE-selectin, TNF-alpha, and MMPs were significantly higher (p< 0.05) in diabetic compared to nondiabetic subjects, while CRP, and sVCAM-1 were significantly higher (p< 0.01) in diabetic compared to nondiabetic subjects. Adiponectin, and Nitrites/Nitrates were significantly lower (p< 0.01) in diabetic compared to nondiabetic subjects. Conclusions: the examined inflammation markers and MMPs are modified in diabetic compared to non diabetic subjects in fasting state and after OGTT.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
