The amygdaloid complex, also known as amygdala, is a heterogeneous group of distinct nuclear and cortical pallial and subpallial structures. The amygdala plays an important role in several complex functions including emotional behavior and learning. GABAergic neurons located in pallial and subpallial amygdala are immunohistochemically heterogeneous regarding the content of calcium binding proteins and peptides, some of which are expressed in separate groups of cells(McDonald, 2020). Vasoactive intestinal polypeptide (VIP) is present in specific subpopulations of GABAergic cells in the amygdala. Although VIP immunoreactivity has been observed in somatodendritic and axonal profiles of the rat basolateral and central amygdala, there is no currently available comprehensive analysis of the distribution of VIP immunoreactivity in the different amygdalar pallial and subpallial structures. The present study utilized immunohistochemical and morphometrical techniques to analyze the distribution and the neuronal localization of VIP immunoreactivity in the rat pallial and subpallial amygdala. In pallial amygdala VIP-IR neurons are local inhibitory interneurons that presumably can regulate directly and indirectly the activity of pyramidal excitatory neurons. In the subpallial amygdala VIP immunoreactivity is expressed in different inhibitory cell types that probably act as projection or local interneurons. The distribution of VIP immunoreactivity is nonhomogeneous throughout the different amygdalar areas, suggesting a distinct impact of this neuropeptide on neuronal amygdaloid circuits activities and, consequently, on the cognitive, emotional, behavioral and endocrine activities amygdala mediated.
DISTRIBUTION OF VASOACTIVE INTESTINAL PEPTIDE (VIP) IMMUNOREACTIVITY IN THE RAT PALLIAL AND SUBPALLIAL AMYGDALA AND COLOCALIZATION WITH γ-AMINOBUTYRIC ACID
Salamanca G.
;Tagliavia C.;Grandis A.;Bombardi C.
2023
Abstract
The amygdaloid complex, also known as amygdala, is a heterogeneous group of distinct nuclear and cortical pallial and subpallial structures. The amygdala plays an important role in several complex functions including emotional behavior and learning. GABAergic neurons located in pallial and subpallial amygdala are immunohistochemically heterogeneous regarding the content of calcium binding proteins and peptides, some of which are expressed in separate groups of cells(McDonald, 2020). Vasoactive intestinal polypeptide (VIP) is present in specific subpopulations of GABAergic cells in the amygdala. Although VIP immunoreactivity has been observed in somatodendritic and axonal profiles of the rat basolateral and central amygdala, there is no currently available comprehensive analysis of the distribution of VIP immunoreactivity in the different amygdalar pallial and subpallial structures. The present study utilized immunohistochemical and morphometrical techniques to analyze the distribution and the neuronal localization of VIP immunoreactivity in the rat pallial and subpallial amygdala. In pallial amygdala VIP-IR neurons are local inhibitory interneurons that presumably can regulate directly and indirectly the activity of pyramidal excitatory neurons. In the subpallial amygdala VIP immunoreactivity is expressed in different inhibitory cell types that probably act as projection or local interneurons. The distribution of VIP immunoreactivity is nonhomogeneous throughout the different amygdalar areas, suggesting a distinct impact of this neuropeptide on neuronal amygdaloid circuits activities and, consequently, on the cognitive, emotional, behavioral and endocrine activities amygdala mediated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
