CORRELATION BETWEEN SERUM URIC ACID AND LEFT VENTRICULAR MASS IN ESSENTIAL HYPERTENSION

Download PDFPDF Poster Presentations Bone diseases other than osteoporosis, metabolic diseases and crystal diseases SAT0317 Correlation Between Serum Uric Acid and Left Ventricular Mass in Essential Hypertension E.R. Rinaldi, C. Bentivenga, E. Cosentino, S. Corvaglia, M. Rosticci, L. Magnani, I. Ricci Iamino, A.F. Cicero, N. Malavolta, C. Borghi Abstract Background Left ventricular hypertrophy (LVH) is an independent and powerful risk factor for cardiovascular events and death. Serum uric acid (SUA) may induce LVH, on one hand, through an inflammatory effect which promotes cardiac hypertrophy and, on the other, through an activation of the renin-angiotensin-aldosterone system which generates hypertrophy and hyperplasia of myocytes and fibrosis of the heart Objectives Aim of the study was to investigate the correlation between SUA levels and left ventricular mass in a group of hypertensive patients Methods We evaluated 51 patients (mean age 74±10 years; range 49-87, F 37.7%; M 62.3%) with essential hypertension. Each patient underwent a standardized medical history and clinical examination, laboratory tests and echocardiographic assessment with the determination of left ventricular mass index (LVMI) Results Mean value of SUA was 6.68±2 mg/dl. Mean blood pressure (MAP) was 95±12 mmHg. A positive significant correlation between SUA and LVMI (P=0.029) was observed. After adjusting for MAP and age in standard multiple linear regression analysis, SUA level remains independently associated with LVMI suggesting that increased urate levels are associated with a higher myocardial mass. Conclusions Our results demonstrate that SUA is independently associated with LVMI and suggest that the combination of hyperuricemia with LVH could be a powerful predictor of cardiovascular events