Oxidative stress (OS) plays a key role in autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by deficits in social communication, restricted interests, and repetitive behaviors. Recent evidence suggests that the TLDc [Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic] domain is a highly conserved motif present in proteins that are important players in the OS response and in neuroprotection. Human proteins sharing the TLDc domain include OXR1, TLDC1, NCOA7, TBC1D24, and C20ORF118. This study was aimed at understanding whether TLDc domain-containing mRNAs together with specific microRNAs (200b-3p and 32-5p) and long noncoding RNAs (TUG1), known to target TLDc proteins, contributed to regulate the OS response in ASD. Data showed a significant increase in the levels of OXR1 and TLDC1 mRNAs in peripheral blood mononuclear cells (PBMCs) of ASD children compared to their neurotypically developing (NTD) counterparts, along with an increase in TUG1 mRNA expression levels, suggesting its possible role in the regulation of TLDc proteins. A positive correlation between the expression of some TLDc mRNAs and the Childhood Autism Rating Scale (CARS) global score as well as inflammatory gene expression was found. In conclusion, our data suggest a novel biological pathway in the OS response of ASD subjects that deserves further exploration.

Zucchini, C., Serpe, C., De Sanctis, P., Ghezzo, A., Visconti, P., Posar, A., et al. (2023). TLDc Domain-Containing Genes in Autism Spectrum Disorder: New Players in the Oxidative Stress Response. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(21), 1-13 [10.3390/ijms242115802].

TLDc Domain-Containing Genes in Autism Spectrum Disorder: New Players in the Oxidative Stress Response

Zucchini, Cinzia;Serpe, Carmela;De Sanctis, Paola;Ghezzo, Alessandro;Visconti, Paola;Posar, Annio;Facchin, Federica;Marini, Marina
;
Abruzzo, Provvidenza Maria
2023

Abstract

Oxidative stress (OS) plays a key role in autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by deficits in social communication, restricted interests, and repetitive behaviors. Recent evidence suggests that the TLDc [Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic] domain is a highly conserved motif present in proteins that are important players in the OS response and in neuroprotection. Human proteins sharing the TLDc domain include OXR1, TLDC1, NCOA7, TBC1D24, and C20ORF118. This study was aimed at understanding whether TLDc domain-containing mRNAs together with specific microRNAs (200b-3p and 32-5p) and long noncoding RNAs (TUG1), known to target TLDc proteins, contributed to regulate the OS response in ASD. Data showed a significant increase in the levels of OXR1 and TLDC1 mRNAs in peripheral blood mononuclear cells (PBMCs) of ASD children compared to their neurotypically developing (NTD) counterparts, along with an increase in TUG1 mRNA expression levels, suggesting its possible role in the regulation of TLDc proteins. A positive correlation between the expression of some TLDc mRNAs and the Childhood Autism Rating Scale (CARS) global score as well as inflammatory gene expression was found. In conclusion, our data suggest a novel biological pathway in the OS response of ASD subjects that deserves further exploration.
2023
Zucchini, C., Serpe, C., De Sanctis, P., Ghezzo, A., Visconti, P., Posar, A., et al. (2023). TLDc Domain-Containing Genes in Autism Spectrum Disorder: New Players in the Oxidative Stress Response. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(21), 1-13 [10.3390/ijms242115802].
Zucchini, Cinzia; Serpe, Carmela; De Sanctis, Paola; Ghezzo, Alessandro; Visconti, Paola; Posar, Annio; Facchin, Federica; Marini, Marina; Abruzzo, Pr...espandi
File in questo prodotto:
File Dimensione Formato  
ijms-24-15802.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 1.39 MB
Formato Adobe PDF
1.39 MB Adobe PDF Visualizza/Apri
ijms-24-15802-s001.zip

accesso aperto

Tipo: File Supplementare
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 65.69 kB
Formato Zip File
65.69 kB Zip File Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/961572
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact