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EnglishThe present paper reviews biochemical aspects of depression, focusing on abnormalities in: 1) serotonergic neurotransmission; 2) GABA and glutamate systems; 3) substance P; 4) neurosteroids. The results of literature search are discussed as regards their implications for the discovery of novel, more effective antidepressant treatments. Indeed, although depression is traditionally regarded as a treatable mental disorder, up to 50% of such patients may not have a satisfactory remission of symptoms after an adequate antidepressant treatment.
| Titolo: | Biochemistry of depressive disorders. role of serotonin, amino acid neurotransmitters, substance p and neurosteroids |
| Autore/i: | Serretti A.; Olgiati P. |
| Autore/i Unibo: | |
| Anno: | 2008 |
| Rivista: | |
| Abstract: | The present paper reviews biochemical aspects of depression, focusing on abnormalities in: 1) serotonergic neurotransmission; 2) GABA and glutamate systems; 3) substance P; 4) neurosteroids. The results of literature search are discussed as regards their implications for the discovery of novel, more effective antidepressant treatments. Indeed, although depression is traditionally regarded as a treatable mental disorder, up to 50% of such patients may not have a satisfactory remission of symptoms after an adequate antidepressant treatment. |
| Data prodotto definitivo in UGOV: | 2011-01-24 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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