Introduction: Spleen stiffness (SS) has been found to mirror dynamic changes in portal pressure after transjugular intrahepatic portosystemic shunt (TIPS) placement. However, there is no data available regarding SS in patients with spontaneous portosystemic shunting (SPSS), especially in regards to prediction of hepatic decompensation. Methods: We retrospectively selected patients with confirmed SPSS and esophageal varices (EVs) at endoscopic examination, and recorded any decompensating event (i.e., variceal hemorrhage, overt hepatic encephalopathy, refractory ascites, spontaneous bacterial peritonitis, hepatorenal syndrome) in the first twelve months following liver and spleen elastography. Results: The patients who presented decompensating events showed lower platelet count (94.5 vs. 121.5 g/L, p < 0.001), higher SS (44 vs. 30 kPa, p < 0.001), higher probability of EVs according to SS (77 vs. 2 %, p < 0.001), and higher spleen diameter (14 vs. 12 cm, p = 0.043). They also showed a higher prevalence of splenorenal shunts (66.7 vs. 31.2%), and a significantly wider SPSS major diameter (14.5 vs. 8 mm, p < 0.001). Conclusion: SS could predict SPSS efficacy in relieving portal pressure, and could predict decompensating events in patients with SPSS.

Spleen stiffness can be employed to assess the efficacy of spontaneous portosystemic shunts in relieving portal hypertension / Giuffre M.; Bedogni G.; Abazia C.; Masutti F.; Tiribelli C.; Croce L.S.. - In: ANNALS OF HEPATOLOGY. - ISSN 1665-2681. - ELETTRONICO. - 19:6(2020), pp. 691-693. [10.1016/j.aohep.2020.07.004]

Spleen stiffness can be employed to assess the efficacy of spontaneous portosystemic shunts in relieving portal hypertension

Bedogni G.;
2020

Abstract

Introduction: Spleen stiffness (SS) has been found to mirror dynamic changes in portal pressure after transjugular intrahepatic portosystemic shunt (TIPS) placement. However, there is no data available regarding SS in patients with spontaneous portosystemic shunting (SPSS), especially in regards to prediction of hepatic decompensation. Methods: We retrospectively selected patients with confirmed SPSS and esophageal varices (EVs) at endoscopic examination, and recorded any decompensating event (i.e., variceal hemorrhage, overt hepatic encephalopathy, refractory ascites, spontaneous bacterial peritonitis, hepatorenal syndrome) in the first twelve months following liver and spleen elastography. Results: The patients who presented decompensating events showed lower platelet count (94.5 vs. 121.5 g/L, p < 0.001), higher SS (44 vs. 30 kPa, p < 0.001), higher probability of EVs according to SS (77 vs. 2 %, p < 0.001), and higher spleen diameter (14 vs. 12 cm, p = 0.043). They also showed a higher prevalence of splenorenal shunts (66.7 vs. 31.2%), and a significantly wider SPSS major diameter (14.5 vs. 8 mm, p < 0.001). Conclusion: SS could predict SPSS efficacy in relieving portal pressure, and could predict decompensating events in patients with SPSS.
2020
Spleen stiffness can be employed to assess the efficacy of spontaneous portosystemic shunts in relieving portal hypertension / Giuffre M.; Bedogni G.; Abazia C.; Masutti F.; Tiribelli C.; Croce L.S.. - In: ANNALS OF HEPATOLOGY. - ISSN 1665-2681. - ELETTRONICO. - 19:6(2020), pp. 691-693. [10.1016/j.aohep.2020.07.004]
Giuffre M.; Bedogni G.; Abazia C.; Masutti F.; Tiribelli C.; Croce L.S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/960458
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