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Introduction: The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce of 24 RSV worldwide experts assessed key needs for RSV prevention in LMICs, including vaccine and newer preventive measures. Methods: A global, survey-based study was undertaken in 2021. An online questionnaire was developed following three meetings of the Taskforce panellists wherein factors related to RSV infection, its prevention and management were identified using iterative questioning. Each factor was scored, by non-panellists interested in RSV, on a scale of zero (very-low-relevance) to 100 (very-high-relevance) within two scenarios: (1) Current and (2) Future expectations for RSV management. Results: Ninety questionnaires were completed: 70 by respondents (71.4% physicians; 27.1% researchers/scientists) from 16 LMICs and 20 from nine high-income (HI) countries (90.0% physicians; 5.0% researchers/scientists), as a reference group. Within LMICs, RSV awareness was perceived to be low, and management was not prioritised. Of the 100 factors scored, those related to improved diagnosis particularly access to affordable point-of-care diagnostics, disease burden data generation, clinical and general education, prompt access to new interventions, and engagement with policymakers/payers were identified of paramount importance. There was a strong need for clinical education and local data generation in the lowest economies, whereas upper-middle income countries were more closely aligned with HI countries in terms of current RSV service provision. Conclusion: Seven key actions for improving RSV prevention and management in LMICs are proposed.
Identifying the research, advocacy, policy and implementation needs for the prevention and management of respiratory syncytial virus lower respiratory tract infection in low- and middle-income countries / Carbonell-Estrany, Xavier; Simões, Eric A. F; Bont, Louis J; Gentile, Angela; Homaira, Nusrat; Scotta, Marcelo Comerlato; Stein, Renato T; Torres, Juan P; Sheikh, Jarju; Broor, Shobha; Khuri-Bulos, Najwa; Nokes, D James; Munywoki, Patrick K; Bassat, Quique; Sharma, Arun K; Basnet, Sudha; Garba, Maria; De Jesus-Cornejo, Joanne; Lupisan, Socorro P; Nunes, Marta C; Divarathna, Maduja; Fullarton, John R; Rodgers-Gray, Barry S; Keary, Ian; Reñosa, Mark Donald C; Verwey, Charl; Moore, David P; Noordeen, Faseeha; Kabra, Sushil; do Vale, Marynéa Silva; Paternina-De La Ossa, Rolando; Mariño, Cristina; Figueras-Aloy, Josep; Krilov, Leonard; Berezin, Eitan; Zar, Heather J; Paudel, Krishna; Safadi, Marco Aurelio Palazzi; Dbaibo, Ghassan; Jroundi, Imane; Jha, Runa; Rafeek, Rukshan A. M; Pinheiro, Rossiclei de Souza; Bracht, Marianne; Muthugala, Rohitha; Lanari, Marcello; Martinón-Torres, Federico; Mitchell, Ian; Irimu, Grace; Pandey, Apsara; Krishnan, Anand; Mejias, Asuncion; da Costa, Marcela Santos Corrêa; Shrestha, Shrijana; Pernica, Jeffrey M; de Carvalho, Felipe Cotrim; Jalango, Rose E; Ibrahim, Hafsat; Ewa, Atana; Ensinck, Gabriela; Ulloa-Gutierrez, Rolando; Miralha, Alexandre Lopes; Lucion, Maria Florencia; Hassan, Md Zakiul; Akhtar, Zubair; Aleem, Mohammad Abdul; Chowdhury, Fahmida; Rojo, Pablo; Sande, Charles; Musau, Abednego; Zaman, Khalequ; Helena, Luiza; Arlant, Falleiros; Ghimire, Prakash; Price, April; Subedi, Kalpana Upadhyay; Brenes-Chacon, Helena; Goswami, Doli Rani; Rahman, Mohammed Ziaur; Hossain, Mohammad Enayet; Chisti, Mohammod Jobayer; Vain, Nestor E; Lim, Audrey; Chiu, Aaron; Papenburg, Jesse; Juarez, Maria del Valle; Senaratne, Thamarasi; Arunasalam, Shiyamalee; Strand, Tor A; Ayuk, Adaeze; Ogunrinde, Olufemi; Tavares, Lohanna Valeska de Sousa; Garba, Comfort; Garba, Bilkisu I; Dawa, Jeanette; Gordon, Michelle; Osoro, Eric; Agoti, Charles N; Nyawanda, Bryan; Ngama, Mwanajuma; Tabu, Collins; Mathew, Joseph L; Cornacchia, Andrew; Rai, Ganesh Kumar; Jain, Amita; Giongo, Mateus Sfoggia; Paes, Bosco A. - In: FRONTIERS IN PEDIATRICS. - ISSN 2296-2360. - ELETTRONICO. - 10:(2022), pp. 1033125.1-1033125.13. [10.3389/fped.2022.1033125]
Identifying the research, advocacy, policy and implementation needs for the prevention and management of respiratory syncytial virus lower respiratory tract infection in low- and middle-income countries
Carbonell-Estrany, Xavier;Simões, Eric A. F;Bont, Louis J;Gentile, Angela;Homaira, Nusrat;Scotta, Marcelo Comerlato;Stein, Renato T;Torres, Juan P;Sheikh, Jarju;Broor, Shobha;Khuri-Bulos, Najwa;Nokes, D James;Munywoki, Patrick K;Bassat, Quique;Sharma, Arun K;Basnet, Sudha;Garba, Maria;De Jesus-Cornejo, Joanne;Lupisan, Socorro P;Nunes, Marta C;Divarathna, Maduja;Fullarton, John R;Rodgers-Gray, Barry S;Keary, Ian;Reñosa, Mark Donald C;Verwey, Charl;Moore, David P;Noordeen, Faseeha;Kabra, Sushil;do Vale, Marynéa Silva;Paternina-De La Ossa, Rolando;Mariño, Cristina;Figueras-Aloy, Josep;Krilov, Leonard;Berezin, Eitan;Zar, Heather J;Paudel, Krishna;Safadi, Marco Aurelio Palazzi;Dbaibo, Ghassan;Jroundi, Imane;Jha, Runa;Rafeek, Rukshan A. M;Pinheiro, Rossiclei de Souza;Bracht, Marianne;Muthugala, Rohitha;Lanari, Marcello;Martinón-Torres, Federico;Mitchell, Ian;Irimu, Grace;Pandey, Apsara;Krishnan, Anand;Mejias, Asuncion;da Costa, Marcela Santos Corrêa;Shrestha, Shrijana;Pernica, Jeffrey M;de Carvalho, Felipe Cotrim;Jalango, Rose E;Ibrahim, Hafsat;Ewa, Atana;Ensinck, Gabriela;Ulloa-Gutierrez, Rolando;Miralha, Alexandre Lopes;Lucion, Maria Florencia;Hassan, Md Zakiul;Akhtar, Zubair;Aleem, Mohammad Abdul;Chowdhury, Fahmida;Rojo, Pablo;Sande, Charles;Musau, Abednego;Zaman, Khalequ;Helena, Luiza;Arlant, Falleiros;Ghimire, Prakash;Price, April;Subedi, Kalpana Upadhyay;Brenes-Chacon, Helena;Goswami, Doli Rani;Rahman, Mohammed Ziaur;Hossain, Mohammad Enayet;Chisti, Mohammod Jobayer;Vain, Nestor E;Lim, Audrey;Chiu, Aaron;Papenburg, Jesse;Juarez, Maria del Valle;Senaratne, Thamarasi;Arunasalam, Shiyamalee;Strand, Tor A;Ayuk, Adaeze;Ogunrinde, Olufemi;Tavares, Lohanna Valeska de Sousa;Garba, Comfort;Garba, Bilkisu I;Dawa, Jeanette;Gordon, Michelle;Osoro, Eric;Agoti, Charles N;Nyawanda, Bryan;Ngama, Mwanajuma;Tabu, Collins;Mathew, Joseph L;Cornacchia, Andrew;Rai, Ganesh Kumar;Jain, Amita;Giongo, Mateus Sfoggia;Paes, Bosco A
2022
Abstract
Introduction: The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce of 24 RSV worldwide experts assessed key needs for RSV prevention in LMICs, including vaccine and newer preventive measures. Methods: A global, survey-based study was undertaken in 2021. An online questionnaire was developed following three meetings of the Taskforce panellists wherein factors related to RSV infection, its prevention and management were identified using iterative questioning. Each factor was scored, by non-panellists interested in RSV, on a scale of zero (very-low-relevance) to 100 (very-high-relevance) within two scenarios: (1) Current and (2) Future expectations for RSV management. Results: Ninety questionnaires were completed: 70 by respondents (71.4% physicians; 27.1% researchers/scientists) from 16 LMICs and 20 from nine high-income (HI) countries (90.0% physicians; 5.0% researchers/scientists), as a reference group. Within LMICs, RSV awareness was perceived to be low, and management was not prioritised. Of the 100 factors scored, those related to improved diagnosis particularly access to affordable point-of-care diagnostics, disease burden data generation, clinical and general education, prompt access to new interventions, and engagement with policymakers/payers were identified of paramount importance. There was a strong need for clinical education and local data generation in the lowest economies, whereas upper-middle income countries were more closely aligned with HI countries in terms of current RSV service provision. Conclusion: Seven key actions for improving RSV prevention and management in LMICs are proposed.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/960335
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Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
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