Key PointsGenetically induced decay-accelerating factor (DAF) overexpression prevents adriamycin (ADR)-induced focal segmental glomerulosclerosis (FSGS) in mice.Pharmacologic inhibition of DAF cleavage reduces complement activation in the glomeruli and albuminuria in murine ADR-induced FSGS.Inhibition of complement activation represents a valuable therapeutic strategy for FSGS and, potentially, other glomerular diseases.

Decay-Accelerating Factor Expression Modulates the Severity of Experimental Focal Segmental Glomerulosclerosis / Bin S.; Budge K.; Gentile M.; Podesta M.A.; Khan Y.; Azzi J.R.; Russo L.S.; La Manna G.; Cravedi P.. - In: KIDNEY360. - ISSN 2641-7650. - ELETTRONICO. - 4:3(2023), pp. 381-386. [10.34067/KID.0005312022]

Decay-Accelerating Factor Expression Modulates the Severity of Experimental Focal Segmental Glomerulosclerosis

Bin S.;Khan Y.;La Manna G.;
2023

Abstract

Key PointsGenetically induced decay-accelerating factor (DAF) overexpression prevents adriamycin (ADR)-induced focal segmental glomerulosclerosis (FSGS) in mice.Pharmacologic inhibition of DAF cleavage reduces complement activation in the glomeruli and albuminuria in murine ADR-induced FSGS.Inhibition of complement activation represents a valuable therapeutic strategy for FSGS and, potentially, other glomerular diseases.
2023
Decay-Accelerating Factor Expression Modulates the Severity of Experimental Focal Segmental Glomerulosclerosis / Bin S.; Budge K.; Gentile M.; Podesta M.A.; Khan Y.; Azzi J.R.; Russo L.S.; La Manna G.; Cravedi P.. - In: KIDNEY360. - ISSN 2641-7650. - ELETTRONICO. - 4:3(2023), pp. 381-386. [10.34067/KID.0005312022]
Bin S.; Budge K.; Gentile M.; Podesta M.A.; Khan Y.; Azzi J.R.; Russo L.S.; La Manna G.; Cravedi P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/960156
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