Objective: A number of nutraceuticals have demonstrated to signifi cantly lower blood pressure or lipid levels in humans. Our aim was to evaluate the effect of a combination of both blood pressure and lipid lowering nutraceuticals in mildly hypertensive hypercholesterolemic subjects. Design and method: This is a pilot, double-blind, randomized, placebo-controlled, clinical trial carried out on 30 mildly hypertensive hypercholesterolemic subjects in primary prevention for cardiovascular disease, randomized to active treatment or placebo for 2 months. Active treatment contained red yeast rice extract (with 10 mg monacolin per dose), an NO-donor, magnesium, and vitamins. Results: The tested product was well-tolerated by all patients. Subjects in active treatment experienced a signifi cant improvement in morning SBP, DBP, MAP, evening SBP, LDL-C and estimated CV risk vs. placebo (see table). Conclusions: Conclusion: A combined blood pressure and lipid lowering nutraceutical improved morning SBP, DBP, MAP, evening SBP, LDL-C and estimated CV risk vs. placebo in mildly hypertensive hypercholesterolemic subjects.
Cicero, A., Rosticci, M., D'Addato, S., Fogacci, F., Urso, R., Borghi, C. (2016). EFFECTS OF A COMBINED BLOOD PRESSURE AND LIPID-LOWERING NUTRACEUTICAL ON MILDLY HYPERTENSIVE HYPERCHOLESTEROLEMIC SUBJECTS: A PILOT, DOUBLE-BLIND, PLACEBO-CONTROLLED, RCT. JOURNAL OF HYPERTENSION, 34(Supplement 2), 312-312 [10.1097/01.hjh.0000492253.96038.c3].
EFFECTS OF A COMBINED BLOOD PRESSURE AND LIPID-LOWERING NUTRACEUTICAL ON MILDLY HYPERTENSIVE HYPERCHOLESTEROLEMIC SUBJECTS: A PILOT, DOUBLE-BLIND, PLACEBO-CONTROLLED, RCT
Cicero, AFGPrimo
;Rosticci, M;D'Addato, S;Urso, R;Borghi, CUltimo
2016
Abstract
Objective: A number of nutraceuticals have demonstrated to signifi cantly lower blood pressure or lipid levels in humans. Our aim was to evaluate the effect of a combination of both blood pressure and lipid lowering nutraceuticals in mildly hypertensive hypercholesterolemic subjects. Design and method: This is a pilot, double-blind, randomized, placebo-controlled, clinical trial carried out on 30 mildly hypertensive hypercholesterolemic subjects in primary prevention for cardiovascular disease, randomized to active treatment or placebo for 2 months. Active treatment contained red yeast rice extract (with 10 mg monacolin per dose), an NO-donor, magnesium, and vitamins. Results: The tested product was well-tolerated by all patients. Subjects in active treatment experienced a signifi cant improvement in morning SBP, DBP, MAP, evening SBP, LDL-C and estimated CV risk vs. placebo (see table). Conclusions: Conclusion: A combined blood pressure and lipid lowering nutraceutical improved morning SBP, DBP, MAP, evening SBP, LDL-C and estimated CV risk vs. placebo in mildly hypertensive hypercholesterolemic subjects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.