Prostate cancer (PCa) is widely spread in male population, especially over 65 years. Currently used medical methods of PCa diagnosis often lead to false-positive results thus new non-invasive methods for PCa detection, such as urine tests for cancer metabolites, are actively studied. Herein, nanostructured polycrystalline cerium oxide thin films (CeO2/GC) prepared by magnetron sputtering on a glassy carbon substrate are tested for electrochemiluminescent (ECL) detection of sar-cosine exploiting the oxidative-reduction mechanism using Ru(bpy)32+ as luminophore. Non-functionalized CeO2/GC electrodes revealed a higher ECL signal stability compared to bare glassy carbon electrodes. Moreover, CeO2/GC electrodes were successfully applied for rapid and sensitive detection of different sarcosine con-centrations ranging from 50 to 5000 mu M. These results open new possibilities for developing sensing platforms for sarcosine detection based on the CeO2/GC working electrode via surface modification and functionalization, aiming to further investigate and improve their sensitivity and selectivity.

Evaluation of polycrystalline cerium oxide electrodes for electrochemiluminescent detection of sarcosine / Bahrami H.; Kosto Y.; Claudio Ignazio Santo; Yakovlev Y.; Khalakhan I.; Mousavi M.; Matolin V.; Matolinova I.; Paolucci F.; Valenti G.; Tsud N.; Zanut A.. - In: MICROCHEMICAL JOURNAL. - ISSN 0026-265X. - ELETTRONICO. - 187:(2023), pp. 108362.1-108362.6. [10.1016/j.microc.2022.108362]

Evaluation of polycrystalline cerium oxide electrodes for electrochemiluminescent detection of sarcosine

Claudio Ignazio Santo;Paolucci F.;Valenti G.;
2023

Abstract

Prostate cancer (PCa) is widely spread in male population, especially over 65 years. Currently used medical methods of PCa diagnosis often lead to false-positive results thus new non-invasive methods for PCa detection, such as urine tests for cancer metabolites, are actively studied. Herein, nanostructured polycrystalline cerium oxide thin films (CeO2/GC) prepared by magnetron sputtering on a glassy carbon substrate are tested for electrochemiluminescent (ECL) detection of sar-cosine exploiting the oxidative-reduction mechanism using Ru(bpy)32+ as luminophore. Non-functionalized CeO2/GC electrodes revealed a higher ECL signal stability compared to bare glassy carbon electrodes. Moreover, CeO2/GC electrodes were successfully applied for rapid and sensitive detection of different sarcosine con-centrations ranging from 50 to 5000 mu M. These results open new possibilities for developing sensing platforms for sarcosine detection based on the CeO2/GC working electrode via surface modification and functionalization, aiming to further investigate and improve their sensitivity and selectivity.
2023
Evaluation of polycrystalline cerium oxide electrodes for electrochemiluminescent detection of sarcosine / Bahrami H.; Kosto Y.; Claudio Ignazio Santo; Yakovlev Y.; Khalakhan I.; Mousavi M.; Matolin V.; Matolinova I.; Paolucci F.; Valenti G.; Tsud N.; Zanut A.. - In: MICROCHEMICAL JOURNAL. - ISSN 0026-265X. - ELETTRONICO. - 187:(2023), pp. 108362.1-108362.6. [10.1016/j.microc.2022.108362]
Bahrami H.; Kosto Y.; Claudio Ignazio Santo; Yakovlev Y.; Khalakhan I.; Mousavi M.; Matolin V.; Matolinova I.; Paolucci F.; Valenti G.; Tsud N.; Zanut A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/958943
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