Acylation of N-Boc-N-methylhydrazones followed by TFA treatment affords regioselective access to substituted pyrazoles. Both regioisomers of 1-methyl-3,5-disubstituted-1H-pyrazoles can be selectively obtained. This procedure can also be employed for the regioselective preparation of fully substituted 1H-pyrazoles.

Regioselective synthesis of 1,3,5- and 1,3,4,5-substituted pyrazoles via acylation of N-Boc-N-substituted hydrazones

TINARELLI, ALESSANDRO;RIGHI, PAOLO;ROSINI, GOFFREDO;
2011

Abstract

Acylation of N-Boc-N-methylhydrazones followed by TFA treatment affords regioselective access to substituted pyrazoles. Both regioisomers of 1-methyl-3,5-disubstituted-1H-pyrazoles can be selectively obtained. This procedure can also be employed for the regioselective preparation of fully substituted 1H-pyrazoles.
A. Tinarelli; P. Righi; G. Rosini; D. Andreotti; R. Profeta; S. Spada
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/95844
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