Background: Diverticular disease (DD) is a common condition in Western countries. The role of microbiota in the pathogenesis of DD and its related symptoms has been frequently postulated since most complications of this disease are bacteria-driven and most therapies rely on microbiota modulation. Preliminary data showed fecal microbial imbalance in patients with DD, particularly when symptomatic, with an increase of pro-inflammatory and potentially pathogenetic bacteria. In addition, bacterial metabolic markers can mirror specific pathways of the disease and may be even used for monitoring treatment effects. All treatments currently suggested for DD can affect microbiota structure and metabolome compositions. Purpose: Sparse evidence is available linking gut microbiota perturbations, diverticular disease pathophysiology, and symptom development. We aimed to summarize the available knowledge on gut microbiota evaluation in diverticular disease, with a focus on symptomatic uncomplicated DD, and the relative treatment strategies.

The role of microbiota and its modulation in colonic diverticular disease / Marasco G.; Buttitta F.; Cremon C.; Barbaro M.R.; Stanghellini V.; Barbara G.. - In: NEUROGASTROENTEROLOGY AND MOTILITY. - ISSN 1350-1925. - ELETTRONICO. - 35:12(2023), pp. e14615.1-e14615.14. [10.1111/nmo.14615]

The role of microbiota and its modulation in colonic diverticular disease

Marasco G.;Buttitta F.;Barbaro M. R.;Stanghellini V.;Barbara G.
2023

Abstract

Background: Diverticular disease (DD) is a common condition in Western countries. The role of microbiota in the pathogenesis of DD and its related symptoms has been frequently postulated since most complications of this disease are bacteria-driven and most therapies rely on microbiota modulation. Preliminary data showed fecal microbial imbalance in patients with DD, particularly when symptomatic, with an increase of pro-inflammatory and potentially pathogenetic bacteria. In addition, bacterial metabolic markers can mirror specific pathways of the disease and may be even used for monitoring treatment effects. All treatments currently suggested for DD can affect microbiota structure and metabolome compositions. Purpose: Sparse evidence is available linking gut microbiota perturbations, diverticular disease pathophysiology, and symptom development. We aimed to summarize the available knowledge on gut microbiota evaluation in diverticular disease, with a focus on symptomatic uncomplicated DD, and the relative treatment strategies.
2023
The role of microbiota and its modulation in colonic diverticular disease / Marasco G.; Buttitta F.; Cremon C.; Barbaro M.R.; Stanghellini V.; Barbara G.. - In: NEUROGASTROENTEROLOGY AND MOTILITY. - ISSN 1350-1925. - ELETTRONICO. - 35:12(2023), pp. e14615.1-e14615.14. [10.1111/nmo.14615]
Marasco G.; Buttitta F.; Cremon C.; Barbaro M.R.; Stanghellini V.; Barbara G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/957263
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