: Irritable bowel syndrome (IBS) with diarrhea (IBS-D) affects ~1% of the general population and is characterized by abdominal pain associated with diarrhea. IBS-D symptoms significantly impact the quality of life of patients. Major uncertainties remain regarding the optimal management of these patients. Several therapies have been investigated over the years for the treatment of IBS-D. In the initial management, commonly prescribed approaches with an effect on global IBS symptoms include a low Fermentable Oligo-, Di-, Mono-Saccharides and Polyols diet and probiotics, while antispasmodics are used for targeting abdominal pain and loperamide for diarrhea only. Additional therapeutic options for the relief of global IBS symptoms include rifaximin, 5-HT3 antagonists, gut-directed psychological therapies, and eluxadoline, while tricyclic antidepressants can target abdominal pain and bile acid sequestrants diarrhea. Promising evidence exists for the use of mesalazine and fecal microbiota transplantation in IBS-D, although further evidence is needed for definitive conclusions regarding their efficacy.

Management of Irritable Bowel Syndrome With Diarrhea / Marasco, Giovanni; Cremon, Cesare; Barbaro, Maria Raffaella; Stanghellini, Vincenzo; Barbara, Giovanni. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - ELETTRONICO. - 58:3(2024), pp. 221-231. [10.1097/MCG.0000000000001964]

Management of Irritable Bowel Syndrome With Diarrhea

Marasco, Giovanni;Barbaro, Maria Raffaella;Stanghellini, Vincenzo;Barbara, Giovanni
2024

Abstract

: Irritable bowel syndrome (IBS) with diarrhea (IBS-D) affects ~1% of the general population and is characterized by abdominal pain associated with diarrhea. IBS-D symptoms significantly impact the quality of life of patients. Major uncertainties remain regarding the optimal management of these patients. Several therapies have been investigated over the years for the treatment of IBS-D. In the initial management, commonly prescribed approaches with an effect on global IBS symptoms include a low Fermentable Oligo-, Di-, Mono-Saccharides and Polyols diet and probiotics, while antispasmodics are used for targeting abdominal pain and loperamide for diarrhea only. Additional therapeutic options for the relief of global IBS symptoms include rifaximin, 5-HT3 antagonists, gut-directed psychological therapies, and eluxadoline, while tricyclic antidepressants can target abdominal pain and bile acid sequestrants diarrhea. Promising evidence exists for the use of mesalazine and fecal microbiota transplantation in IBS-D, although further evidence is needed for definitive conclusions regarding their efficacy.
2024
Management of Irritable Bowel Syndrome With Diarrhea / Marasco, Giovanni; Cremon, Cesare; Barbaro, Maria Raffaella; Stanghellini, Vincenzo; Barbara, Giovanni. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - ELETTRONICO. - 58:3(2024), pp. 221-231. [10.1097/MCG.0000000000001964]
Marasco, Giovanni; Cremon, Cesare; Barbaro, Maria Raffaella; Stanghellini, Vincenzo; Barbara, Giovanni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/957192
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