The synthetic opioid met-enkephalin analog [D-Ala2, MePhe4, Met(0)5ol] enkephalin (DAMME) and the opiate morphine injected intraperitoneally to rats at doses of 0.5-2 and 5-20 mg/kg, respectively, showed a protective effect on gastric damage induced by oral administration of necrotizing agents (0.6 7NHCl or 0.2 NNaOH solutions, 1 ml/rat). The protection was prevented by naltrexone (10 mg/kg s.c.), an opioid antagonist with long lasting activity. Histological sections of mucosal samples from animals pretreated with morphine (10 mg/kg i.p.) and DAMME (1 mg/kg i.p.) showed less alteration of the columnar epithelium, with a normal glandular structure, than untreated rats. A mediation of prostaglandins is suggested, since indomethacin (10 mg/kg s.c.) significantly reduced the protective effects of opioids. © 1988 S. Karger AG, Basel.

S Ferri, E.S. (1988). Protection by opioids against gastric lesions caused by necrotizing agents: (With 1 color plate). PHARMACOLOGY, 36(2), 140-144 [10.1159/000138371].

Protection by opioids against gastric lesions caused by necrotizing agents: (With 1 color plate)

S Candeletti;P Romualdi;
1988

Abstract

The synthetic opioid met-enkephalin analog [D-Ala2, MePhe4, Met(0)5ol] enkephalin (DAMME) and the opiate morphine injected intraperitoneally to rats at doses of 0.5-2 and 5-20 mg/kg, respectively, showed a protective effect on gastric damage induced by oral administration of necrotizing agents (0.6 7NHCl or 0.2 NNaOH solutions, 1 ml/rat). The protection was prevented by naltrexone (10 mg/kg s.c.), an opioid antagonist with long lasting activity. Histological sections of mucosal samples from animals pretreated with morphine (10 mg/kg i.p.) and DAMME (1 mg/kg i.p.) showed less alteration of the columnar epithelium, with a normal glandular structure, than untreated rats. A mediation of prostaglandins is suggested, since indomethacin (10 mg/kg s.c.) significantly reduced the protective effects of opioids. © 1988 S. Karger AG, Basel.
1988
S Ferri, E.S. (1988). Protection by opioids against gastric lesions caused by necrotizing agents: (With 1 color plate). PHARMACOLOGY, 36(2), 140-144 [10.1159/000138371].
S Ferri , E Speroni, S Candeletti, E Cavicchini, P Romualdi, P Govoni, M Marchini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/956982
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