Radiofrequency lesion of medial basal hypothalamus (MBH) caused a approximately 50% depletion of immunoreactive dynorphin (ir-dyn) both in the anterior and neurointermediate lobe of the pituitary, whereas radiofrequency lesions of both supraoptic and paraventricular nuclei (SON, PVN) resulted in an approximately 30% reduction in neurointermediate lobe only. MBH cells and/or fibers contribute, therefore, to adenohypophysis pool of ir-dyn. Moreover, since the loss of ir-dyn in neurohypophysis ascertained after MBH lesion is significantly higher than that obtained with SON and PVN destruction, it may be assumed that MBH also participate to ir-dyn pool in neurohypophysis.
Spampinato S., Candeletti S., Romualdi P., Russo A., Stanzani S., Ferri S. (1983). Effects of hypothalamic lesions on the content of dynorphin immunoreactivity in pituitary. LIFE SCIENCES, 33(SUPPL. 1), 503-506 [10.1016/0024-3205(83)90551-9].
Effects of hypothalamic lesions on the content of dynorphin immunoreactivity in pituitary
Spampinato S.;Candeletti S.;Romualdi P.;
1983
Abstract
Radiofrequency lesion of medial basal hypothalamus (MBH) caused a approximately 50% depletion of immunoreactive dynorphin (ir-dyn) both in the anterior and neurointermediate lobe of the pituitary, whereas radiofrequency lesions of both supraoptic and paraventricular nuclei (SON, PVN) resulted in an approximately 30% reduction in neurointermediate lobe only. MBH cells and/or fibers contribute, therefore, to adenohypophysis pool of ir-dyn. Moreover, since the loss of ir-dyn in neurohypophysis ascertained after MBH lesion is significantly higher than that obtained with SON and PVN destruction, it may be assumed that MBH also participate to ir-dyn pool in neurohypophysis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
