Purpose: Idiopathic normal pressure hydrocephalus (iNPH) is associated with an increased prevalence of open-angle glaucoma, attributed to variations of the pressure gradient between intraocular and intracranial compartments at the level of the lamina cribrosa (LC). As ocular biomechanics influence the behavior of the LC, and a lower corneal hysteresis (CH) has been associated to a higher risk of glaucomatous optic nerve damage, in this study we compared ocular biomechanics of iNPH patients with healthy subjects. Methods:  Twenty-four eyes of 24 non-shunted iNPH patients were prospectively recruited. Ocular biomechanical properties were investigated using the ocular response analyzer (Reichert Instruments) for the calculation of the CH, corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc). Results were compared with those of 25 eyes of 25 healthy subjects. Results:  In iNPH eyes, the median CH value and interquartile range (IQR) were 9.7 mmHg (7.8-10) and 10.6 mmHg (9.3-11.3) in healthy controls (p = 0.015). No significant differences were found in IOPcc [18.1 mmHg (14.72-19.92) vs. 16.4 mmHg (13.05-19.6)], IOPg [15.4 mmHg (12.82-19.7) vs. 15.3 mmHg (12.55-17.35)], and CRF [9.65 mmHg (8.07-11.65) vs. 10.3 mmHg (9.3-11.5)] between iNPH patients and controls. Conclusions:  In iNPH patients, the CH was significantly lower compared to healthy subjects. This result suggests that ocular biomechanical properties may potentially contribute to the risk of development of glaucomatous optic nerve damage in iNPH patients.

In vivo assessment of the ocular biomechanical properties in patients with idiopathic normal pressure hydrocephalus / Valsecchi, Nicola; Roda, Matilde; Febbraro, Simone; Trolli, Eleonora; Palandri, Giorgio; Giannini, Giulia; Milletti, David; Schiavi, Costantino; Fontana, Luigi. - In: INTERNATIONAL OPHTHALMOLOGY. - ISSN 1573-2630. - ELETTRONICO. - 44:1(2024), pp. 1-8. [10.1007/s10792-024-02922-3]

In vivo assessment of the ocular biomechanical properties in patients with idiopathic normal pressure hydrocephalus

Valsecchi, Nicola
Primo
Investigation
;
Roda, Matilde
Secondo
Formal Analysis
;
Febbraro, Simone
Writing – Original Draft Preparation
;
Trolli, Eleonora
Data Curation
;
Giannini, Giulia
Formal Analysis
;
Milletti, David
Data Curation
;
Schiavi, Costantino
Penultimo
Validation
;
Fontana, Luigi
Ultimo
Supervision
2024

Abstract

Purpose: Idiopathic normal pressure hydrocephalus (iNPH) is associated with an increased prevalence of open-angle glaucoma, attributed to variations of the pressure gradient between intraocular and intracranial compartments at the level of the lamina cribrosa (LC). As ocular biomechanics influence the behavior of the LC, and a lower corneal hysteresis (CH) has been associated to a higher risk of glaucomatous optic nerve damage, in this study we compared ocular biomechanics of iNPH patients with healthy subjects. Methods:  Twenty-four eyes of 24 non-shunted iNPH patients were prospectively recruited. Ocular biomechanical properties were investigated using the ocular response analyzer (Reichert Instruments) for the calculation of the CH, corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc). Results were compared with those of 25 eyes of 25 healthy subjects. Results:  In iNPH eyes, the median CH value and interquartile range (IQR) were 9.7 mmHg (7.8-10) and 10.6 mmHg (9.3-11.3) in healthy controls (p = 0.015). No significant differences were found in IOPcc [18.1 mmHg (14.72-19.92) vs. 16.4 mmHg (13.05-19.6)], IOPg [15.4 mmHg (12.82-19.7) vs. 15.3 mmHg (12.55-17.35)], and CRF [9.65 mmHg (8.07-11.65) vs. 10.3 mmHg (9.3-11.5)] between iNPH patients and controls. Conclusions:  In iNPH patients, the CH was significantly lower compared to healthy subjects. This result suggests that ocular biomechanical properties may potentially contribute to the risk of development of glaucomatous optic nerve damage in iNPH patients.
2024
In vivo assessment of the ocular biomechanical properties in patients with idiopathic normal pressure hydrocephalus / Valsecchi, Nicola; Roda, Matilde; Febbraro, Simone; Trolli, Eleonora; Palandri, Giorgio; Giannini, Giulia; Milletti, David; Schiavi, Costantino; Fontana, Luigi. - In: INTERNATIONAL OPHTHALMOLOGY. - ISSN 1573-2630. - ELETTRONICO. - 44:1(2024), pp. 1-8. [10.1007/s10792-024-02922-3]
Valsecchi, Nicola; Roda, Matilde; Febbraro, Simone; Trolli, Eleonora; Palandri, Giorgio; Giannini, Giulia; Milletti, David; Schiavi, Costantino; Fontana, Luigi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/956765
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