Background: MicroRNAs are important modulators of gene expression but their role in the atrophy program and in muscle loss is unknown. Results: miRNA-206 and miRNA-21 are critical for regulation of the atrophy program after denervation. Conclusion: miRNAs are important for the fine-tuning of the atrophy program. Significance: Modulating miRNA expression is a novel potential therapeutic approach for counteracting muscle loss and weakness in catabolic conditions. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Soares R.J., Cagnin S., Chemello F., Silvestrin M., Musaro A., De Pitta C., et al. (2014). Involvement of MicroRNAs in the regulation of muscle wasting during catabolic conditions. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 289(32), 21909-21925 [10.1074/jbc.M114.561845].
Involvement of MicroRNAs in the regulation of muscle wasting during catabolic conditions
Chemello F.;
2014
Abstract
Background: MicroRNAs are important modulators of gene expression but their role in the atrophy program and in muscle loss is unknown. Results: miRNA-206 and miRNA-21 are critical for regulation of the atrophy program after denervation. Conclusion: miRNAs are important for the fine-tuning of the atrophy program. Significance: Modulating miRNA expression is a novel potential therapeutic approach for counteracting muscle loss and weakness in catabolic conditions. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
