Kikuchi-Fujimoto disease (KFD) is a benign self-limiting disorder that frequently leads to swelling of cervical lymph nodes in young women. It has a characteristic histologic appearance with sharply demarcated foci containing apoptotic debris, histiocytes, and proliferating large T-cells. Since in the past years, core needle biopsies have been increasingly used for diagnostic work-up, a small biopsy of the pathognomonic proliferating T-cell foci may lead to misinterpretation as a large T-cell neoplasia. The aim of the present study therefore was to analyze how frequently clonal T-cell receptor (TCR) amplificates may be obtained in KFD using a commonly used TCR gamma rearrangement clonality assay. In 88 KFD cases, TCR gamma clonality assays could be successfully applied. Clonal peaks of TCR gamma in front of a polyclonal background were observed in 15 cases (18%). The investigated clinical parameters (age, gender, extent of infiltration of the lymph node, percentage of proliferative compart-ment) did not differ between patients with detectable TCR gamma clones from those patients who had polyclonal TCR gamma results.
Clonal T-cell proliferations occasionally occur in Kikuchi-Fujimoto disease / Hartmann, Sylvia; Melle, Federica; Motta, Giovanna; Agostinelli, Claudio; Sabattini, Elena; Pileri, Stefano; Hansmann, Martin-Leo. - In: HUMAN PATHOLOGY. - ISSN 0046-8177. - STAMPA. - 138:(2023), pp. 103-111. [10.1016/j.humpath.2023.06.003]
Clonal T-cell proliferations occasionally occur in Kikuchi-Fujimoto disease
Melle, Federica;Agostinelli, Claudio;Sabattini, Elena;Pileri, Stefano;
2023
Abstract
Kikuchi-Fujimoto disease (KFD) is a benign self-limiting disorder that frequently leads to swelling of cervical lymph nodes in young women. It has a characteristic histologic appearance with sharply demarcated foci containing apoptotic debris, histiocytes, and proliferating large T-cells. Since in the past years, core needle biopsies have been increasingly used for diagnostic work-up, a small biopsy of the pathognomonic proliferating T-cell foci may lead to misinterpretation as a large T-cell neoplasia. The aim of the present study therefore was to analyze how frequently clonal T-cell receptor (TCR) amplificates may be obtained in KFD using a commonly used TCR gamma rearrangement clonality assay. In 88 KFD cases, TCR gamma clonality assays could be successfully applied. Clonal peaks of TCR gamma in front of a polyclonal background were observed in 15 cases (18%). The investigated clinical parameters (age, gender, extent of infiltration of the lymph node, percentage of proliferative compart-ment) did not differ between patients with detectable TCR gamma clones from those patients who had polyclonal TCR gamma results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.