After hyperventilation, systolic and diastolic blood pressure (BP) significantly decreased in 14 hypertensive patients (group 1), did not change in 9 (group 2) and increased in 8 (group 3). Basal BP, norepinephrine and dynorphin B levels were higher in group 1 than in groups 2 and 3. The decrease in BP after hyperventilation was associated with a decrease in plasma norepinephrine, Met-enkephalin and dynorphin B and an increase in β-endorphin. Naloxone abolished the hyperventilation-induced BP and norepinephrine decreases. Our findings indicate that hyperventilation may select hypertensive patients with different sympatho-adrenergic activity and that the increase in β-endorphin reduces BP response to hyperventilation in patients with high sympatho-adrenergic tone. © 2002 Elsevier Science Inc. All rights reserved.
β-Endorphin modulation of pressor response to hyperventilation in hypertensive patients / Fontana F.; Bernardi P.; Spampinato S.; Di Toro R.; Bugiardini R.. - In: PEPTIDES. - ISSN 0196-9781. - STAMPA. - 23:5(2002), pp. 911-918. [10.1016/S0196-9781(02)00018-9]
β-Endorphin modulation of pressor response to hyperventilation in hypertensive patients
Fontana F.;Bernardi P.;Spampinato S.;Di Toro R.;Bugiardini R.Ultimo
2002
Abstract
After hyperventilation, systolic and diastolic blood pressure (BP) significantly decreased in 14 hypertensive patients (group 1), did not change in 9 (group 2) and increased in 8 (group 3). Basal BP, norepinephrine and dynorphin B levels were higher in group 1 than in groups 2 and 3. The decrease in BP after hyperventilation was associated with a decrease in plasma norepinephrine, Met-enkephalin and dynorphin B and an increase in β-endorphin. Naloxone abolished the hyperventilation-induced BP and norepinephrine decreases. Our findings indicate that hyperventilation may select hypertensive patients with different sympatho-adrenergic activity and that the increase in β-endorphin reduces BP response to hyperventilation in patients with high sympatho-adrenergic tone. © 2002 Elsevier Science Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.