After hyperventilation, systolic and diastolic blood pressure (BP) significantly decreased in 14 hypertensive patients (group 1), did not change in 9 (group 2) and increased in 8 (group 3). Basal BP, norepinephrine and dynorphin B levels were higher in group 1 than in groups 2 and 3. The decrease in BP after hyperventilation was associated with a decrease in plasma norepinephrine, Met-enkephalin and dynorphin B and an increase in β-endorphin. Naloxone abolished the hyperventilation-induced BP and norepinephrine decreases. Our findings indicate that hyperventilation may select hypertensive patients with different sympatho-adrenergic activity and that the increase in β-endorphin reduces BP response to hyperventilation in patients with high sympatho-adrenergic tone. © 2002 Elsevier Science Inc. All rights reserved.

β-Endorphin modulation of pressor response to hyperventilation in hypertensive patients

Fontana F.;Bernardi P.;Spampinato S.;Di Toro R.;Bugiardini R.
Ultimo
2002

Abstract

After hyperventilation, systolic and diastolic blood pressure (BP) significantly decreased in 14 hypertensive patients (group 1), did not change in 9 (group 2) and increased in 8 (group 3). Basal BP, norepinephrine and dynorphin B levels were higher in group 1 than in groups 2 and 3. The decrease in BP after hyperventilation was associated with a decrease in plasma norepinephrine, Met-enkephalin and dynorphin B and an increase in β-endorphin. Naloxone abolished the hyperventilation-induced BP and norepinephrine decreases. Our findings indicate that hyperventilation may select hypertensive patients with different sympatho-adrenergic activity and that the increase in β-endorphin reduces BP response to hyperventilation in patients with high sympatho-adrenergic tone. © 2002 Elsevier Science Inc. All rights reserved.
2002
Fontana F.; Bernardi P.; Spampinato S.; Di Toro R.; Bugiardini R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/954331
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