Apolipoprotein(a) (apo(a)) is the protein component that defines lipoprotein(a) (Lp(a)) particles and is encoded by the LPA gene. The apo(a) is extremely heterogeneous in size due to the copy number variations in the kringle-IV type 2 (KIV2) domains. In this review, we aim to discuss the role of genetics in establishing Lp(a) as a risk factor for coronary heart disease (CHD) by examining a series of molecular biology techniques aimed at identifying the best strategy for a possible application in clinical research and practice, according to the current gold standard.
Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods / Fogacci F, Di Micoli V, Avagimyan A, Giovannini M, Imbalzano E, Cicero AFG. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 24:18(2023), pp. 13886.1-13886.14. [10.3390/ijms241813886]
Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
Di Micoli VSecondo
Writing – Original Draft Preparation
;Giovannini MWriting – Review & Editing
;Cicero AFG
Ultimo
Conceptualization
2023
Abstract
Apolipoprotein(a) (apo(a)) is the protein component that defines lipoprotein(a) (Lp(a)) particles and is encoded by the LPA gene. The apo(a) is extremely heterogeneous in size due to the copy number variations in the kringle-IV type 2 (KIV2) domains. In this review, we aim to discuss the role of genetics in establishing Lp(a) as a risk factor for coronary heart disease (CHD) by examining a series of molecular biology techniques aimed at identifying the best strategy for a possible application in clinical research and practice, according to the current gold standard.| File | Dimensione | Formato | |
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Fogacci F_Assessment of Apolipoprotein(a) Isoform Size_Int J Mol Sci.pdf
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