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Background: Surgery is the primary treatment that can offer potential cure for gastric cancer, but is associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, the aim of this study was to develop a core outcome set (COS) - a standardized group of outcomes important to key international stakeholders - that should be reported by future trials in this field. Methods: Stage 1 of the study involved identifying potentially important outcomes from previous trials and a series of patient interviews. Stage 2 involved patients and healthcare professionals prioritizing outcomes using a multilanguage international Delphi survey that informed an international consensus meeting at which the COS was finalized. Results: Some 498 outcomes were identified from previously reported trials and patient interviews, and rationalized into 56 items presented in the Delphi survey. A total of 952 patients, surgeons, and nurses enrolled in round 1 of the survey, and 662 (70 per cent) completed round 2. Following the consensus meeting, eight outcomes were included in the COS: disease-free survival, disease-specific survival, surgery-related death, recurrence, completeness of tumour removal, overall quality of life, nutritional effects, and 'serious' adverse events. Conclusion: A COS for surgical trials in gastric cancer has been developed with international patients and healthcare professionals. This is a minimum set of outcomes that is recommended to be used in all future trials in this field to improve trial design and synthesis of evidence.
Alkhaffaf B., Metryka A., Blazeby J.M., Glenny A.-M., Adeyeye A., Costa P.M., et al. (2021). Core outcome set for surgical trials in gastric cancer (GASTROS study): international patient and healthcare professional consensus. BRITISH JOURNAL OF SURGERY, 108(10), 1216-1224 [10.1093/bjs/znab192].
Core outcome set for surgical trials in gastric cancer (GASTROS study): international patient and healthcare professional consensus
Alkhaffaf B.;Metryka A.;Blazeby J. M.;Glenny A. -M.;Adeyeye A.;Costa P. M.;Diez Del Val I.;Gisbertz S. S.;Guner A.;Law S.;Lee H. -J.;Li Z.;Nakada K.;Reim D.;Vorwald P.;Baiocchi G. L.;Allum W.;Chaudry M. A.;Griffiths E. A.;Williamson P. R.;Bruce I. A.;Li S.;He Y. L.;Xu Z.;Xue Y.;Liang H.;Li G.;Zhao E.;Neumann P.;O'neill L.;Guinan E.;Zanotti D.;De Manzoni G.;Hagens E. R. C.;Van Berge Henegouwen M. I.;Lages P.;Onofre S.;Restrepo Nunez R. M.;Cabanas G. S.;Gonzalez M. P.;Campos C. M.;Candas B.;Baki B. E.;Bodur M. S.;Yildirim R.;Cekic A. B.;Brown J.;Hayes K.;Daher I.;Gianchandani Moorjani R. H.;Adeyeye A. A.;Olayide A. S.;Leon-Takahashi A. M.;Rabanal A. P.;Peri A.;Boddy A.;Novotny A.;Charalabopoulos A.;Alemdar A.;Souadka A.;Rodrigues Gomes A. M.;Lazaro A.;Da Silva A. M.;Silva e Santos A. D. R. D. C.;Guidi A.;Silva Bernardes A. J.;Quinn A.;Isik A.;Slipek A. A.;Candas B.;Altinbas B. C.;Alegbeleye B. J.;Eom B. W.;Frittoli B.;Lonsdale B.;Rogers B.;Ammori B. J.;Rau B.;Molteni B.;Byrne B. E.;Villacis-Bermeo B. A.;Villacis Gallardo B. E.;Kose B.;Sampedro Nogueira C. J.;Loureiro C.;Oliveira De Sousa C. M.;Collins C. G.;Ekwunife C. N.;Osuagwu C. C.;Wong C. L. -Y.;Winkler C.;Reim D.;Kjaer D. W.;Cooper D.;Horner D.;Irvine D.;Bowrey D. J.;Chuter D. J.;Elliot D.;Mcghee D.;Toth D.;Ofner D.;Manatakis D. K.;Silveira Martins D. R.;Belt E. J. T.;Cattaneo E.;Samadov E.;Colak E.;Treppiedi E.;Guglielmi E.;Redondo-Villahoz E.;Ciferri E.;Graaf E. T. -D.;Cocozza E.;Pape E.;Drozdov E. S.;Enrico F.;Rashid F.;Marco F.;Rosa F.;Navarro F. M.;Perrotta F. S.;Chan F. S. -Y.;Saavedra Tomasich F. D.;Takeda F. R.;Farrell F.;Wuraola F. O.;Rosero G.;Bevilacqua G.;Baronio G.;Mura G.;De Manzoni G.;D'eugenio G.;Ortega-Perez G.;Tilt G.;Sutcliffe G.;Mureddu G.;Guerra Jacob G.;Daneri G. H.;Gbenga H. O.;Okabe H.;Smith I. K.;Lateef I. O.;Garosio I.;Hatipoglu I.;Gockel I.;Negoi I.;Min I. S. -H.;Mesquita I. M. M.;Del Val I. D.;Leemhuis J. H. F.;Gossage J. A.;Weindelmayer J.;Izbicki J. R.;Manson J. M.;Kelly J.;Stoot J. H. M. B.;Haveman J. W.;Brown J. D.;Sultan J.;Hassall J.;Van Sandick J.;Saunders J. H.;Clarke J. K.;Heisterkamp J.;Vargas R J. I.;Couselo Villanueva J. M.;Ingmire J.;Mcewen J.;Alvarez J. G.;Turner J.;Peng J.;Roberts K.;Brandon K. G.;Mitchell K.;Mccarthy K.;Akhtar K.;Mikhailovich K. N.;Corbelli L.;Milhomem L. M.;Solaini L.;Fengyuan L.;Xinchun L.;Timmermans L.;Porritt L.;Taglietti L.;Bonavina L.;Pinheiro L. F.;De Los Angeles Mayo Ossorio M.;Schiavo M.;Marchesiello M.;Das Dores Vieira Leite M.;Demois M.;Gonzalez M. P.;Di Felice M. T.;Van Berge Henegouwen M. I.;De Sousa M. D.;Takahashi M.;Forshaw M.;Berselli M.;Paro M.;Usta M. A.;Yan M. -H.;Pinchin M.;Caprioli M.;Rubbini M.;Cowen M.;Herrera Servin M. A.;Li M. -Z.;Sasako M.;Jahit M. S.;Muhinga M. N.;Tareen M. A.;Ahmad M. F.;Bodur M. S.;Kaban M.;Farooq N.;Coburn N.;Cooper N.;Blencowe N. S.;Loria N.;De Vries N.;Andreollo N. A.;Koksal N.;Zanini N.;Kreuser N.;Okkabaz N.;Damiana O.;Afuwape O.;Fasiku O. K.;Comensoli O.;Koroye O. F.;Capener P.;Morgagni P.;Pernadas Lages P. M.;Wilkerson P. M.;Turner P.;Dutton P.;Hayes P.;Vorwald P.;Singh P.;Gan Q.;Seenivasagam R. K.;Seshadri R. A.;Castro R. G.;Douglas R.;Koshy R. M.;Ylldlrlm R.;Skipworth R. J. E.;Gould R. A.;Wetherill R. C.;Shaw R.;Burley R. A.;Palatucci R.;Racalbuto R.;Correia Casaca R. M.;Lagarde S. M.;Gana S.;Marietti S.;Qureshi S.;Morales-Conde S.;Molfino S.;Barreto S. G.;Turkyilmaz S.;Turan-Trabzon S.;Frisch S.;Castoldi S.;Belloni S.;Flisi S.;Galloway S.;Maria S. R.;Royston S.;Boyle T.;Sezer T. O.;Mengardo V.;Martin V. C.;Wills V. L.;Owen-Holt V.;Casagrande V.;Al-Khyatt W.;Jansen W.;Wang W.;Eshuis W.;Polkowski W. P.;Huang X.;Wang X.;Chen X. -Z.;Dominguez Y. G.;Wang Y.;Viswanath Y. K. S.;He Y. -L.;Demir Z.;Na Z.
2021
Abstract
Background: Surgery is the primary treatment that can offer potential cure for gastric cancer, but is associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, the aim of this study was to develop a core outcome set (COS) - a standardized group of outcomes important to key international stakeholders - that should be reported by future trials in this field. Methods: Stage 1 of the study involved identifying potentially important outcomes from previous trials and a series of patient interviews. Stage 2 involved patients and healthcare professionals prioritizing outcomes using a multilanguage international Delphi survey that informed an international consensus meeting at which the COS was finalized. Results: Some 498 outcomes were identified from previously reported trials and patient interviews, and rationalized into 56 items presented in the Delphi survey. A total of 952 patients, surgeons, and nurses enrolled in round 1 of the survey, and 662 (70 per cent) completed round 2. Following the consensus meeting, eight outcomes were included in the COS: disease-free survival, disease-specific survival, surgery-related death, recurrence, completeness of tumour removal, overall quality of life, nutritional effects, and 'serious' adverse events. Conclusion: A COS for surgical trials in gastric cancer has been developed with international patients and healthcare professionals. This is a minimum set of outcomes that is recommended to be used in all future trials in this field to improve trial design and synthesis of evidence.
Alkhaffaf B., Metryka A., Blazeby J.M., Glenny A.-M., Adeyeye A., Costa P.M., et al. (2021). Core outcome set for surgical trials in gastric cancer (GASTROS study): international patient and healthcare professional consensus. BRITISH JOURNAL OF SURGERY, 108(10), 1216-1224 [10.1093/bjs/znab192].
Alkhaffaf B.; Metryka A.; Blazeby J.M.; Glenny A.-M.; Adeyeye A.; Costa P.M.; Diez Del Val I.; Gisbertz S.S.; Guner A.; Law S.; Lee H.-J.; Li Z.; Naka...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/953630
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
