: Nickel homeostasis in many bacteria is controlled by the nickel-sensor NikR. A recent study by Cao et al. found that Escherichia coli NikR undergoes phase separation and that this event enhances its function as a nickel-dependent transcriptional repressor. The results suggest that phase separation is functional for bacterial metal homeostasis.
Zambelli B. (2023). Intracellular phase separation and its role in nickel sensing. TRENDS IN CELL BIOLOGY, 33(9), 732-733 [10.1016/j.tcb.2023.06.008].
Intracellular phase separation and its role in nickel sensing
Zambelli B.
2023
Abstract
: Nickel homeostasis in many bacteria is controlled by the nickel-sensor NikR. A recent study by Cao et al. found that Escherichia coli NikR undergoes phase separation and that this event enhances its function as a nickel-dependent transcriptional repressor. The results suggest that phase separation is functional for bacterial metal homeostasis.File in questo prodotto:
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NikR_LLPS_TCB.pdf
Open Access dal 11/07/2024
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