Cancer cells reprogram their metabolism to support their growth. Since the discovery of the Warburg effect, several other metabolic alterations and metabolites have been described in cancer cells, including lactate, glutamine, and lipid metabolism reprogramming. Together these alterations provide rapidly dividing tumor cells with metabolic intermediates needed for nucleotide, protein, and fatty acid biosynthesis. MicroRNAs are a class of small non-coding RNAs involved in the regulation of virtually all biological pathways. Altered microRNA expression patterns are associated with the onset and development of several diseases, including cancer. Tumor suppressor microRNAs targeting molecules involved in tumor metabolism are frequently downregulated in cancers. Therefore, microRNAs can serve as potential tumor biomarkers and also represent interesting therapeutic targets. This review summarizes recent findings about microRNAs involved in the regulation of tumor metabolism.

MicroRNAs as regulators of tumor metabolism / Ruggieri F.; Jonas K.; Ferracin M.; Dengler M.; Jӓger V.; Pichler M.. - In: ENDOCRINE-RELATED CANCER. - ISSN 1479-6821. - ELETTRONICO. - 30:8(2023), pp. e220267.220267-e220267.220267. [10.1530/ERC-22-0267]

MicroRNAs as regulators of tumor metabolism

Ruggieri F.;Ferracin M.;
2023

Abstract

Cancer cells reprogram their metabolism to support their growth. Since the discovery of the Warburg effect, several other metabolic alterations and metabolites have been described in cancer cells, including lactate, glutamine, and lipid metabolism reprogramming. Together these alterations provide rapidly dividing tumor cells with metabolic intermediates needed for nucleotide, protein, and fatty acid biosynthesis. MicroRNAs are a class of small non-coding RNAs involved in the regulation of virtually all biological pathways. Altered microRNA expression patterns are associated with the onset and development of several diseases, including cancer. Tumor suppressor microRNAs targeting molecules involved in tumor metabolism are frequently downregulated in cancers. Therefore, microRNAs can serve as potential tumor biomarkers and also represent interesting therapeutic targets. This review summarizes recent findings about microRNAs involved in the regulation of tumor metabolism.
2023
MicroRNAs as regulators of tumor metabolism / Ruggieri F.; Jonas K.; Ferracin M.; Dengler M.; Jӓger V.; Pichler M.. - In: ENDOCRINE-RELATED CANCER. - ISSN 1479-6821. - ELETTRONICO. - 30:8(2023), pp. e220267.220267-e220267.220267. [10.1530/ERC-22-0267]
Ruggieri F.; Jonas K.; Ferracin M.; Dengler M.; Jӓger V.; Pichler M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/952215
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