Facilitation of Ca2+ entry into cells enhances Ca2+ activated events such as transmitter release and stimulation of second messenger systems. We have found a long lasting prepulse facilitation (up to 3-fold) of the cardiac Ca2+ channel alpha(1C)beta(1b) that lasts for tens of seconds without altering current kinetics. The voltage-and time-dependence of the installation of facilitation was characterized as well as the time-and use-dependence of the decay of facilitation. The degree of facilitation was correlated with the coupling efficiency between the charge movement and pore opening channels that were poorly coupled prior to facilitation exhibited the largest facilitation. (C) 1998 Federation of European Biochemical Societies.
Costantin, J.L., Qin, N., Zhou, J., Platano, D., Birnbaumer, L., Stefani, E. (1998). Long lasting facilitation of the rabbit cardiac Ca2+ channel: correlation with the coupling efficiency between charge movement and pore opening. FEBS LETTERS, 423(2), 213-217 [10.1016/s0014-5793(98)00092-1].
Long lasting facilitation of the rabbit cardiac Ca2+ channel: correlation with the coupling efficiency between charge movement and pore opening
Platano, D;
1998
Abstract
Facilitation of Ca2+ entry into cells enhances Ca2+ activated events such as transmitter release and stimulation of second messenger systems. We have found a long lasting prepulse facilitation (up to 3-fold) of the cardiac Ca2+ channel alpha(1C)beta(1b) that lasts for tens of seconds without altering current kinetics. The voltage-and time-dependence of the installation of facilitation was characterized as well as the time-and use-dependence of the decay of facilitation. The degree of facilitation was correlated with the coupling efficiency between the charge movement and pore opening channels that were poorly coupled prior to facilitation exhibited the largest facilitation. (C) 1998 Federation of European Biochemical Societies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
