Background: Periocular malignancies may be clinically different from the examples arising at other sites, with possible delayed diagnosis and greater challenges for treatment and repair. Line-field confocal optical coherence tomography (LC-OCT) is a recently developed technique characterized by an unprecedented capacity to acquire high-definition images in vertical and horizontal modes. In this study, we aimed to investigate the LC-OCT morphological features of a series of eyelid skin lesions, correlating them to histopathological findings. Methods: Patients with biopsy-proven equivocal skin lesion in the eyelid area, previously investigated by means of LC-OCT, were included in the study. Percentage overall agreement was estimated for LC-OCT and histopathological diagnosis for study cases. Results: A total of 51 patients (28 women, 23 men; mean age 66.4 years old), for a total of 51 skin lesions, were assessed. The histopathological diagnosis consisted of 30 malignant and 21 benign tumors. Different entities were characterized by peculiar findings in LC-OCT, alike to histopathological features, allowing for an accurate "in vivo" classification in almost all cases, with a diagnostic concordance with histopathology of 92.1% (47/51). Conclusions: By integrating this new imaging technique into the assessment of suspicious tumors in this area, diagnostic accuracy may increase, improving strategies adopted in multidisciplinary meetings and patient-centered care.

Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions / Di Stefani, Alessandro; Cappilli, Simone; Cuffaro, Giovanni; Fionda, Bruno; Pagliara, Monica Maria; Paradisi, Andrea; Ricci, Costantino; Rossi, Ernesto; Sammarco, Maria Grazia; Schinzari, Giovanni; Tagliaferri, Luca; Blasi, Maria Antonietta; Cinotti, Elisa; Moro, Alessandro; Savino, Gustavo; Suppa, Mariano; Peris, Ketty. - In: DIAGNOSTICS. - ISSN 2075-4418. - ELETTRONICO. - 13:23(2023), pp. 3590-3590. [10.3390/diagnostics13233590]

Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions

Ricci, Costantino;
2023

Abstract

Background: Periocular malignancies may be clinically different from the examples arising at other sites, with possible delayed diagnosis and greater challenges for treatment and repair. Line-field confocal optical coherence tomography (LC-OCT) is a recently developed technique characterized by an unprecedented capacity to acquire high-definition images in vertical and horizontal modes. In this study, we aimed to investigate the LC-OCT morphological features of a series of eyelid skin lesions, correlating them to histopathological findings. Methods: Patients with biopsy-proven equivocal skin lesion in the eyelid area, previously investigated by means of LC-OCT, were included in the study. Percentage overall agreement was estimated for LC-OCT and histopathological diagnosis for study cases. Results: A total of 51 patients (28 women, 23 men; mean age 66.4 years old), for a total of 51 skin lesions, were assessed. The histopathological diagnosis consisted of 30 malignant and 21 benign tumors. Different entities were characterized by peculiar findings in LC-OCT, alike to histopathological features, allowing for an accurate "in vivo" classification in almost all cases, with a diagnostic concordance with histopathology of 92.1% (47/51). Conclusions: By integrating this new imaging technique into the assessment of suspicious tumors in this area, diagnostic accuracy may increase, improving strategies adopted in multidisciplinary meetings and patient-centered care.
2023
Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions / Di Stefani, Alessandro; Cappilli, Simone; Cuffaro, Giovanni; Fionda, Bruno; Pagliara, Monica Maria; Paradisi, Andrea; Ricci, Costantino; Rossi, Ernesto; Sammarco, Maria Grazia; Schinzari, Giovanni; Tagliaferri, Luca; Blasi, Maria Antonietta; Cinotti, Elisa; Moro, Alessandro; Savino, Gustavo; Suppa, Mariano; Peris, Ketty. - In: DIAGNOSTICS. - ISSN 2075-4418. - ELETTRONICO. - 13:23(2023), pp. 3590-3590. [10.3390/diagnostics13233590]
Di Stefani, Alessandro; Cappilli, Simone; Cuffaro, Giovanni; Fionda, Bruno; Pagliara, Monica Maria; Paradisi, Andrea; Ricci, Costantino; Rossi, Ernesto; Sammarco, Maria Grazia; Schinzari, Giovanni; Tagliaferri, Luca; Blasi, Maria Antonietta; Cinotti, Elisa; Moro, Alessandro; Savino, Gustavo; Suppa, Mariano; Peris, Ketty
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/950739
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