Endometrial cancer arising in adenomyosis (EC-AIA) is a rare uterine disease characterized by the malignant transformation of the ectopic endometrium within the adenomyotic foci. Clinicopathological and survival data are mostly limited to case reports and a few cohort studies. We aimed to assess the clinicopathological features and survival outcomes of women with EC-AIA through a systematic review of the literature. Six electronic databases were searched, from 2002 to 2022, for all peer-reviewed studies that reported EC-AIA cases. Thirty-seven EC-AIA patients from 27 case reports and four case series were included in our study. In our analysis, EC-AIA appeared as a rare disease that mainly occurs in menopausal women, shares symptoms with endometrial cancer, and is challenging to diagnose preoperatively. Differently from EC, it shows a higher prevalence of the non-endometrioid histotype, advanced FIGO stages, and p53-signature, which might be responsible for its worse prognosis. Future studies are necessary, to confirm our findings and further investigate this rare condition.
Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review / Raffone A.; Raimondo D.; Maletta M.; Travaglino A.; Renzulli F.; Neola D.; De Laurentiis U.; De Laurentiis F.; Mabrouk M.; Ianieri M.M.; Seracchioli R.; Casadio P.; Mollo A.. - In: CANCERS. - ISSN 2072-6694. - ELETTRONICO. - 15:4(2023), pp. 1142.1-1142.14. [10.3390/cancers15041142]
Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review
Raffone A.;Raimondo D.
;Maletta M.
;Renzulli F.;De Laurentiis U.;De Laurentiis F.;Seracchioli R.;Casadio P.;
2023
Abstract
Endometrial cancer arising in adenomyosis (EC-AIA) is a rare uterine disease characterized by the malignant transformation of the ectopic endometrium within the adenomyotic foci. Clinicopathological and survival data are mostly limited to case reports and a few cohort studies. We aimed to assess the clinicopathological features and survival outcomes of women with EC-AIA through a systematic review of the literature. Six electronic databases were searched, from 2002 to 2022, for all peer-reviewed studies that reported EC-AIA cases. Thirty-seven EC-AIA patients from 27 case reports and four case series were included in our study. In our analysis, EC-AIA appeared as a rare disease that mainly occurs in menopausal women, shares symptoms with endometrial cancer, and is challenging to diagnose preoperatively. Differently from EC, it shows a higher prevalence of the non-endometrioid histotype, advanced FIGO stages, and p53-signature, which might be responsible for its worse prognosis. Future studies are necessary, to confirm our findings and further investigate this rare condition.File | Dimensione | Formato | |
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