Effective radiation therapy aims to maximize the radiation dose delivered to the tumor, while minimizing damage to the surrounding healthy tissues, which can be a challenging task when the tissue-tumor space is small. To eliminate the damage to healthy tissue, it is now possible to inject biocompatible hydrogels between cancerous targets and surrounding tissues to create a spacer pocket. Conventional methods have limitations in poor target visualization and device tracking. In this article, we leverage our MR-tracking technique to develop a novel injection needle for hydrogel spacer deployment. Herein, we present the working principle and fabrication method, followed by benchtop validation in an agar phantom, and magnetic resonance imaging (MRI)-guided validation in tissue-mimic prostate phantom and sexually mature female swine. Animal trials indicated that the spacer pockets in the rectovaginal septum can be accurately visualized on T2-weighted MRI. The experimental results showed that the vaginal-rectal spacing was successfully increased by 12 +/- 2 mm anterior-posterior.
Anthony L. Gunderman, Ehud J. Schmidt, Qingyu Xiao, Junichi Tokuda, Ravi T. Seethamraju, Luca Neri, et al. (2023). {MRI}-Conditional Eccentric-Tube Injection Needle: Design, Fabrication, and Animal Trial. IEEE/ASME TRANSACTIONS ON MECHATRONICS, 28, 2405-2410 [10.1109/tmech.2022.3232546].
{MRI}-Conditional Eccentric-Tube Injection Needle: Design, Fabrication, and Animal Trial
Luca Neri;
2023
Abstract
Effective radiation therapy aims to maximize the radiation dose delivered to the tumor, while minimizing damage to the surrounding healthy tissues, which can be a challenging task when the tissue-tumor space is small. To eliminate the damage to healthy tissue, it is now possible to inject biocompatible hydrogels between cancerous targets and surrounding tissues to create a spacer pocket. Conventional methods have limitations in poor target visualization and device tracking. In this article, we leverage our MR-tracking technique to develop a novel injection needle for hydrogel spacer deployment. Herein, we present the working principle and fabrication method, followed by benchtop validation in an agar phantom, and magnetic resonance imaging (MRI)-guided validation in tissue-mimic prostate phantom and sexually mature female swine. Animal trials indicated that the spacer pockets in the rectovaginal septum can be accurately visualized on T2-weighted MRI. The experimental results showed that the vaginal-rectal spacing was successfully increased by 12 +/- 2 mm anterior-posterior.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
