Supramolecular and biocompatible hydrogels with a tunable pH ranging from 5.5 to 7.6 lead to a wide variety of formulations useful for many different topical applications compatible with the skin pH. An in vitro viability/cytotoxicity test of the gel components demonstrated that they are non-toxic, as the cells continue to proliferate after 48 h. An analysis of the mechanical properties demonstrates that the hydrogels have moderate strength and an excellent linear viscoelastic range with the absence of a proper breaking point, confirmed with thixotropy experiments. Two cosmetic active peptides (Trifluoroacetyl tripeptide-2 and Palmitoyl tripeptide-5) were successfully added to the hydrogels and their transdermal permeation was analysed with Franz diffusion cells. The liquid chromatography-mass spectrometry (HPLC-MS) analyses of the withdrawn samples from the receiving solutions showed that Trifluoroacetyl tripeptide-2 permeated in a considerable amount while almost no transdermal permeation of Palmitoyl tripeptide-5 was observed.

Shariati Pour, S.R., Oddis, S., Barbalinardo, M., Ravarino, P., Cavallini, M., Fiori, J., et al. (2023). Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels. MOLECULES, 28(6), 2528-2539 [10.3390/molecules28062528].

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

Shariati Pour, Seyedeh Rojin
Primo
;
Barbalinardo, Marianna;Ravarino, Paolo;Fiori, Jessica;Giuri, Demetra
;
Tomasini, Claudia
2023

Abstract

Supramolecular and biocompatible hydrogels with a tunable pH ranging from 5.5 to 7.6 lead to a wide variety of formulations useful for many different topical applications compatible with the skin pH. An in vitro viability/cytotoxicity test of the gel components demonstrated that they are non-toxic, as the cells continue to proliferate after 48 h. An analysis of the mechanical properties demonstrates that the hydrogels have moderate strength and an excellent linear viscoelastic range with the absence of a proper breaking point, confirmed with thixotropy experiments. Two cosmetic active peptides (Trifluoroacetyl tripeptide-2 and Palmitoyl tripeptide-5) were successfully added to the hydrogels and their transdermal permeation was analysed with Franz diffusion cells. The liquid chromatography-mass spectrometry (HPLC-MS) analyses of the withdrawn samples from the receiving solutions showed that Trifluoroacetyl tripeptide-2 permeated in a considerable amount while almost no transdermal permeation of Palmitoyl tripeptide-5 was observed.
2023
Shariati Pour, S.R., Oddis, S., Barbalinardo, M., Ravarino, P., Cavallini, M., Fiori, J., et al. (2023). Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels. MOLECULES, 28(6), 2528-2539 [10.3390/molecules28062528].
Shariati Pour, Seyedeh Rojin; Oddis, Sara; Barbalinardo, Marianna; Ravarino, Paolo; Cavallini, Massimiliano; Fiori, Jessica; Giuri, Demetra; Tomasini,...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/941736
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