The recently demonstrated reliance of glycolytic cancer cells on trans-plasma membrane electron transport (tPMET) for survival raises the question of its suitability as a target for anticancer drug development. In this study, the effects of several new and known compounds on proliferation, tPMET activity and NAD(P)H intrinsic fluorescence in human myelogenous leukemic cell lines were investigated. The whole data confirm the importance of tPMET in leukemic cell survival and suggest this activity as a new potential anti-leukemic target.

Inhibition of trans-Plasma Membrane Electron Transport: a potential anti-leukemic strategy

PRATA, CECILIA;VIECELI DALLA SEGA, FRANCESCO;CALICETI, CRISTIANA;ZAMBONIN, LAURA;FIORENTINI, DIANA;HAKIM, GABRIELE;LANDI, LAURA
2010

Abstract

The recently demonstrated reliance of glycolytic cancer cells on trans-plasma membrane electron transport (tPMET) for survival raises the question of its suitability as a target for anticancer drug development. In this study, the effects of several new and known compounds on proliferation, tPMET activity and NAD(P)H intrinsic fluorescence in human myelogenous leukemic cell lines were investigated. The whole data confirm the importance of tPMET in leukemic cell survival and suggest this activity as a new potential anti-leukemic target.
Prata C; Grasso C; Loizzo S; Vieceli Dalla Sega F; Caliceti C; Zambonin L; Fiorentini D; Hakim G; Berridge MV; Landi L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/93758
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