Abstract Italy’s shift to a tertiary economy has modified the working market, concentrating demand also on unqualified one, which includes most immigrants. It is also well established that low socio-economical conditions are associated with an increased prevalence of H. pylori infection. The aims of this study were to compare: (1) the efficacy of a 7 days triple therapy in immigrant and in Italian patients; (2) the prevalence of PUD between these two groups of patients. A total of 116 consecutive immigrant and 112 Italian H. pylori infected patients were recruited between 2007 and 2008. Patients underwent 13C-UBT, endoscopy with biopsies, and were offered a 7-day triple therapy. Eradication rate (ER) was assessed 8 weeks after the end of the treatment using 13C-UBT. The two populations differed for median age (p\0.01), prevalence of PUD (p\0.01), and smoking status (p\0.01). The ER according to the ITT analysis was 70% for Italian and 48.3% for immigrant (p\0.01). Multivariate analysis including country of origin, sex, age, PUD, smoking, and alcohol status found that immigrant had an adjusted OR for not eradicating of 2.14 (p = 0.03). In immigrant patients resident in Italy, performance of triple therapy was lower than expected. Further studies are demanded to confirm and clarify these intriguing results
Helicobacter pylori eradication: Are we really all equal? A controlled study in native and immigrant population / Gatta L; Di Mario F; Vaira D; Franzé A; Rugge M; Pilotto A; Lucarini P; Lera M; Fiorini G; Castelli V; Kaio E; Scarpignato C.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - ELETTRONICO. - 6:(2011), pp. 35-39. [10.1007/s11739-010-0443-0]
Helicobacter pylori eradication: Are we really all equal? A controlled study in native and immigrant population
GATTA, LUIGI;VAIRA, BERARDINO;FIORINI, GIULIA;CASTELLI, VALENTINA;
2011
Abstract
Abstract Italy’s shift to a tertiary economy has modified the working market, concentrating demand also on unqualified one, which includes most immigrants. It is also well established that low socio-economical conditions are associated with an increased prevalence of H. pylori infection. The aims of this study were to compare: (1) the efficacy of a 7 days triple therapy in immigrant and in Italian patients; (2) the prevalence of PUD between these two groups of patients. A total of 116 consecutive immigrant and 112 Italian H. pylori infected patients were recruited between 2007 and 2008. Patients underwent 13C-UBT, endoscopy with biopsies, and were offered a 7-day triple therapy. Eradication rate (ER) was assessed 8 weeks after the end of the treatment using 13C-UBT. The two populations differed for median age (p\0.01), prevalence of PUD (p\0.01), and smoking status (p\0.01). The ER according to the ITT analysis was 70% for Italian and 48.3% for immigrant (p\0.01). Multivariate analysis including country of origin, sex, age, PUD, smoking, and alcohol status found that immigrant had an adjusted OR for not eradicating of 2.14 (p = 0.03). In immigrant patients resident in Italy, performance of triple therapy was lower than expected. Further studies are demanded to confirm and clarify these intriguing resultsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
