A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis / Liu X; Invernizzi P; Lu Y; Kosoy R; Lu Y; Bianchi I; Podda M; Xu C; Xie G; Macciardi F; Selmi C; Lupoli S; Shigeta R; Ransom M; Lleo A; Lee AT; Mason AL; Myers RP; Peltekian KM; Ghent CN; Bernuzzi F; Zuin M; Rosina F; Borghesio E; Floreani A; Lazzari R; Niro G; Andriulli A; Muratori L; Muratori P; Almasio PL; Andreone P; Margotti M; Brunetto M; Coco B; Alvaro D; Bragazzi MC; Marra F; Pisano A; Rigamonti C; Colombo M; Marzioni M; Benedetti A; Fabris L; Strazzabosco M; Portincasa P; Palmieri VO; Tiribelli C; Croce L; Bruno S; Rossi S; Vinci M; Prisco C; Mattalia A; Toniutto P; Picciotto A; Galli A; Ferrari C; Colombo S; Casella G; Morini L; Caporaso N; Colli A; Spinzi G; Montanari R; Gregersen PK; Heathcote EJ; Hirschfield GM; Siminovitch KA; Amos CI; Gershwin ME; Seldin MF.. - In: NATURE GENETICS. - ISSN 1061-4036. - STAMPA. - 42:8(2010), pp. 658-660. [10.1038/ng.627]
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
MURATORI, LUIGI;MURATORI, PAOLO;ANDREONE, PIETRO;MARGOTTI, MARZIA;
2010
Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
