The goal of this work is to develop nasal formulations of THA based on bovine serum albumin nanoparticles (NPL BSA) with -cyclodextrin (CD) and some of its derivatives such as hydroxypropyl -cyclodextrin (HPCD) and sulphobutyl ether -cyclodextrin (SBECD), as permeation enhancers (2,3). Thermal analysis supported by FTIR spectroscopy was used for solid-state characterization of NPL BSA systems. Powders were characterized for drug content, morphology, size distribution and surface charge, as well as for mucoadhesion properties and ex-vivo drug permeation ability.
B. Luppi, F. Bigucci, G. Corace, T. Cerchiara, M. Sorrenti, L. Catenacci, et al. (2010). ALBUMIN NANOPARTICLES CARRYING PERMEATION ENHANCERS FOR NASAL DELIVERY OF TACRINE HYDROCHLORIDE. PARMA : s.n.
ALBUMIN NANOPARTICLES CARRYING PERMEATION ENHANCERS FOR NASAL DELIVERY OF TACRINE HYDROCHLORIDE
LUPPI, BARBARA;BIGUCCI, FEDERICA;CORACE, GIUSEPPE;CERCHIARA, TERESA;DI PIETRA, ANNA MARIA;ZECCHI, VITTORIO
2010
Abstract
The goal of this work is to develop nasal formulations of THA based on bovine serum albumin nanoparticles (NPL BSA) with -cyclodextrin (CD) and some of its derivatives such as hydroxypropyl -cyclodextrin (HPCD) and sulphobutyl ether -cyclodextrin (SBECD), as permeation enhancers (2,3). Thermal analysis supported by FTIR spectroscopy was used for solid-state characterization of NPL BSA systems. Powders were characterized for drug content, morphology, size distribution and surface charge, as well as for mucoadhesion properties and ex-vivo drug permeation ability.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
