The goal of this work is to develop nasal formulations of THA based on bovine serum albumin nanoparticles (NPL BSA) with -cyclodextrin (CD) and some of its derivatives such as hydroxypropyl -cyclodextrin (HPCD) and sulphobutyl ether -cyclodextrin (SBECD), as permeation enhancers (2,3). Thermal analysis supported by FTIR spectroscopy was used for solid-state characterization of NPL BSA systems. Powders were characterized for drug content, morphology, size distribution and surface charge, as well as for mucoadhesion properties and ex-vivo drug permeation ability.
ALBUMIN NANOPARTICLES CARRYING PERMEATION ENHANCERS FOR NASAL DELIVERY OF TACRINE HYDROCHLORIDE
LUPPI, BARBARA;BIGUCCI, FEDERICA;CORACE, GIUSEPPE;CERCHIARA, TERESA;DI PIETRA, ANNA MARIA;ZECCHI, VITTORIO
2010
Abstract
The goal of this work is to develop nasal formulations of THA based on bovine serum albumin nanoparticles (NPL BSA) with -cyclodextrin (CD) and some of its derivatives such as hydroxypropyl -cyclodextrin (HPCD) and sulphobutyl ether -cyclodextrin (SBECD), as permeation enhancers (2,3). Thermal analysis supported by FTIR spectroscopy was used for solid-state characterization of NPL BSA systems. Powders were characterized for drug content, morphology, size distribution and surface charge, as well as for mucoadhesion properties and ex-vivo drug permeation ability.File in questo prodotto:
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