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EnglishThe goal of this work is to develop nasal formulations of THA based on bovine serum albumin nanoparticles (NPL BSA) with -cyclodextrin (CD) and some of its derivatives such as hydroxypropyl -cyclodextrin (HPCD) and sulphobutyl ether -cyclodextrin (SBECD), as permeation enhancers (2,3). Thermal analysis supported by FTIR spectroscopy was used for solid-state characterization of NPL BSA systems. Powders were characterized for drug content, morphology, size distribution and surface charge, as well as for mucoadhesion properties and ex-vivo drug permeation ability.
| Titolo: | ALBUMIN NANOPARTICLES CARRYING PERMEATION ENHANCERS FOR NASAL DELIVERY OF TACRINE HYDROCHLORIDE | |
| Autore/i: | LUPPI, BARBARA; BIGUCCI, FEDERICA; CORACE, GIUSEPPE; CERCHIARA, TERESA; M. Sorrenti; L. Catenacci; DI PIETRA, ANNA MARIA; G. Bettinetti; ZECCHI, VITTORIO | |
| Autore/i Unibo: | ||
| Anno: | 2010 | |
| Titolo del libro: | Meeting on Lactose as a Carrier for Inhalation Products | |
| Pagina iniziale: | 105 | |
| Pagina finale: | 106 | |
| Abstract: | The goal of this work is to develop nasal formulations of THA based on bovine serum albumin nanoparticles (NPL BSA) with -cyclodextrin (CD) and some of its derivatives such as hydroxypropyl -cyclodextrin (HPCD) and sulphobutyl ether -cyclodextrin (SBECD), as permeation enhancers (2,3). Thermal analysis supported by FTIR spectroscopy was used for solid-state characterization of NPL BSA systems. Powders were characterized for drug content, morphology, size distribution and surface charge, as well as for mucoadhesion properties and ex-vivo drug permeation ability. | |
| Data prodotto definitivo in UGOV: | 30-nov-2010 | |
| Appare nelle tipologie: | 4.01 Contributo in Atti di convegno |
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