Mutations of the p53 tumour suppressor gene on chromosome 17p are a common genetic change in the malignant progression of many cancers. Here we report a case of a 71-year-old man with haematological, cytofluorimetric and cytochemical findings consistent with a 'de novo' M2 acute myeloid leukaemia (AML). A complex karyotype including a whole chromosome 17 and a t(17;?) (p11;?) was present in 8 of 10 metaphases of bone marrow cells. Southern blot analysis of the bone marrow DNA showed a specific loss of p53 gene in the AML cells. As far as we know, this is the first report of a deletion of both p53 alleles in leukaemia. The effect of the loss of p53 on the course of AML is discussed.

Gandini D, Cuneo A, Carli MG, Lanza F, Castoldi GL, del Senno L. (1994). Total loss of p53 DNA sequences in acute myeloid leukemia. LEUKEMIA RESEARCH, 18(1), 63-65 [10.1016/0145-2126(94)90011-6].

Total loss of p53 DNA sequences in acute myeloid leukemia

Cuneo A;Lanza F
Membro del Collaboration Group
;
1994

Abstract

Mutations of the p53 tumour suppressor gene on chromosome 17p are a common genetic change in the malignant progression of many cancers. Here we report a case of a 71-year-old man with haematological, cytofluorimetric and cytochemical findings consistent with a 'de novo' M2 acute myeloid leukaemia (AML). A complex karyotype including a whole chromosome 17 and a t(17;?) (p11;?) was present in 8 of 10 metaphases of bone marrow cells. Southern blot analysis of the bone marrow DNA showed a specific loss of p53 gene in the AML cells. As far as we know, this is the first report of a deletion of both p53 alleles in leukaemia. The effect of the loss of p53 on the course of AML is discussed.
1994
Gandini D, Cuneo A, Carli MG, Lanza F, Castoldi GL, del Senno L. (1994). Total loss of p53 DNA sequences in acute myeloid leukemia. LEUKEMIA RESEARCH, 18(1), 63-65 [10.1016/0145-2126(94)90011-6].
Gandini D; Cuneo A; Carli MG; Lanza F; Castoldi GL; del Senno L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/923671
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