What is known about the RegentK regenerative treatment for ruptured anterior cruciate ligament? A scoping review

Background Conservative/regenerative therapy for cruciate ligament ruptures can be considered as primary treatment. However, nowadays, the first option is almost always only surgical, although studies on the efficacy of intervention exist in the literature. Objective This scoping review aimed to map and summarize the literature to identify interventions with RegentK treatment available for cruciate ligament ruptures. Methods Four databases were searched until May 2022. Studies that considered anterior cruciate ruptures treated with the RegentK method could be included. All interventions and contexts were considered. No restrictions were applied regarding language, study design, or publication type. No grey literature and reference lists of included articles were identified. Results were presented in numerical and thematic form. Results From 245 initial records, 7 studies met the inclusion criteria. Most of the articles were randomized controlled trials (RCTs) and considered sports patients with cruciate ligament ruptures. The authors discuss only one range of interventions: conservative (n = 7); specifically, the conservative/regenerative RegentK treatment. Conclusion This is the first scoping review that provides a comprehensive overview of the topic. The results revealed clear gaps in primary research, confirming that current management is based on surgery. This review may be useful for overall management and may provide a starting point for future research.