High-throughput ion channel screening for drug discovery is the gold standard for investigating the function of chan- nel proteins and it is at the base of the recent shift of resources in the pharmaceutical industry towards addressing drug safety issues earlier in the discovery process. This paper presents a versatile, low-cost and disposable microfluidic device realized using a micromilling process fa- brication of polyoxymethilene homopolymer (DelrinTM) substrates. The devices are suitable to host lipid bilayer mem- brane arrays for ion channel recording activities using a fully automated approach and are embedded in a parallel readout hybrid electronic system.

A Disposable Microfluidic Array Platform for Automatic Ion Channel Recording

ROSSI, MICHELE;THEI, FEDERICO;TARTAGNI, MARCO
2010

Abstract

High-throughput ion channel screening for drug discovery is the gold standard for investigating the function of chan- nel proteins and it is at the base of the recent shift of resources in the pharmaceutical industry towards addressing drug safety issues earlier in the discovery process. This paper presents a versatile, low-cost and disposable microfluidic device realized using a micromilling process fa- brication of polyoxymethilene homopolymer (DelrinTM) substrates. The devices are suitable to host lipid bilayer mem- brane arrays for ion channel recording activities using a fully automated approach and are embedded in a parallel readout hybrid electronic system.
Proceedings of Micro-TAS 2010
1913
1915
M. Rossi; F. Thei; H. Morgan; M. Tartagni
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/92057
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