We characterized 61 Gardnerella vaginalis (GV) strains isolated from women with bacterial vaginosis. GV clade 1 was the most commonly found (52.5%), followed by clade 4 (36.1%). All the strains were susceptible to ampicillin and clindamycin, whereas 96.7% and 6.6% of strains showed metronidazole and tetracycline resistance, respectively. Isolates within clade 4 tended to possess the highest ability to form biofilm. Strains resistant to metronidazole and tetracycline were all intermediate or high biofilm producers. All GV clades significantly upregulated the production of pro-inflammatory cytokines by HeLa cells, especially IL-8 and IL-6. Clade 4 induced a significantly higher production of IL-1β compared to other clades.

Morselli, S., Salvo, M., Foschi, C., Lazzarotto, T., Ambretti, S., Marangoni, A. (2023). Characterization of Gardnerella vaginalis isolates: correlations among clades, biofilm formation and cytokine stimulation. NEW MICROBIOLOGICA, 46(1), 56-59.

Characterization of Gardnerella vaginalis isolates: correlations among clades, biofilm formation and cytokine stimulation

Morselli, Sara;Salvo, Melissa;Foschi, Claudio
;
Lazzarotto, Tiziana;Ambretti, Simone;Marangoni, Antonella
2023

Abstract

We characterized 61 Gardnerella vaginalis (GV) strains isolated from women with bacterial vaginosis. GV clade 1 was the most commonly found (52.5%), followed by clade 4 (36.1%). All the strains were susceptible to ampicillin and clindamycin, whereas 96.7% and 6.6% of strains showed metronidazole and tetracycline resistance, respectively. Isolates within clade 4 tended to possess the highest ability to form biofilm. Strains resistant to metronidazole and tetracycline were all intermediate or high biofilm producers. All GV clades significantly upregulated the production of pro-inflammatory cytokines by HeLa cells, especially IL-8 and IL-6. Clade 4 induced a significantly higher production of IL-1β compared to other clades.
2023
Morselli, S., Salvo, M., Foschi, C., Lazzarotto, T., Ambretti, S., Marangoni, A. (2023). Characterization of Gardnerella vaginalis isolates: correlations among clades, biofilm formation and cytokine stimulation. NEW MICROBIOLOGICA, 46(1), 56-59.
Morselli, Sara; Salvo, Melissa; Foschi, Claudio; Lazzarotto, Tiziana; Ambretti, Simone; Marangoni, Antonella
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/920232
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