Doxorubicin (DOX)/CaCO 3 single crystals act as pH responsive drug carrier. A biomimetic approach demonstrates that calcite single crystals are able, during their growth in the presence of doxorubicin, to entrap drug molecules inside their lattice along specifi c crystallographic directions. Alterations in lattice dimensions and microstructural parameters are determined by means of high-resolution synchrotron powder diffraction measurements. Confocal microscopy confi rms that doxorubicin is uniformly embedded in the crystal and is not simply adsorbed on the crystal surface. A slow release of DOX was obtained preferentially in the proximity of the crystals, targeting cancer cells.
Magnabosco G., Di Giosia M., Polishchuk I., Weber E., Fermani S., Bottoni A., et al. (2015). Correction to Calcite Single Crystals as Hosts for Atomic-Scale Entrapment and Slow Release of Drugs [Adv. Healthcare Mater. 4, (2015), 1510-1516] doi: 10.1002/adhm.201500170. ADVANCED HEALTHCARE MATERIALS, 4(13), 1899-1899 [10.1002/adhm.201500631].
Correction to Calcite Single Crystals as Hosts for Atomic-Scale Entrapment and Slow Release of Drugs [Adv. Healthcare Mater. 4, (2015), 1510-1516] doi: 10.1002/adhm.201500170
Magnabosco G.;Di Giosia M.;Fermani S.;Bottoni A.;Zerbetto F.;Rapino S.
;Falini G.
;Calvaresi M.
2015
Abstract
Doxorubicin (DOX)/CaCO 3 single crystals act as pH responsive drug carrier. A biomimetic approach demonstrates that calcite single crystals are able, during their growth in the presence of doxorubicin, to entrap drug molecules inside their lattice along specifi c crystallographic directions. Alterations in lattice dimensions and microstructural parameters are determined by means of high-resolution synchrotron powder diffraction measurements. Confocal microscopy confi rms that doxorubicin is uniformly embedded in the crystal and is not simply adsorbed on the crystal surface. A slow release of DOX was obtained preferentially in the proximity of the crystals, targeting cancer cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
