Patients with acute lymphoblastic leukemia (ALL) are characterized by an unfavorable outcome in the majority of adult cases. Several clinical trials have confirmed the usefulness of a pediatric-type therapy applied to adult patients. Adults present with higher risk features at diagnosis that predispose them to chemotherapy resistance and disease relapse after an initial achievement of complete remission. The recent introduction of novel immune-targeted therapies, including monoclonal antibodies (MoAbs) targeting B cell-associated antigens such as CD19 (blinatumumab) and CD22 (inotuzumab), tyrosine kinase inhibitors targeting BCR-ABL1 tyrosine kinase, bispecific antibodies and chimeric antigen receptor T- cell therapy (CAR-T), circumvent B-ALL cell chemo-refractoriness through novel mechanisms of action, potentially eradicating minimal residual disease (MRD) and enabling more patients to receive allogeneic hematopoietic stem cell transplantation and to achieve a better clinical outcome.

Lanza, F., Maffini, E., Saraceni, F., Massari, E., Rondoni, M., Daghia, G., et al. (2020). New monoclonal antibodies and tyrosine kinase inhibitors in B-cell acute lymphoblastic leukemia. MINERVA MEDICA, 111(5), 478-490 [10.23736/S0026-4806.20.07031-7].

New monoclonal antibodies and tyrosine kinase inhibitors in B-cell acute lymphoblastic leukemia

Lanza, Francesco;
2020

Abstract

Patients with acute lymphoblastic leukemia (ALL) are characterized by an unfavorable outcome in the majority of adult cases. Several clinical trials have confirmed the usefulness of a pediatric-type therapy applied to adult patients. Adults present with higher risk features at diagnosis that predispose them to chemotherapy resistance and disease relapse after an initial achievement of complete remission. The recent introduction of novel immune-targeted therapies, including monoclonal antibodies (MoAbs) targeting B cell-associated antigens such as CD19 (blinatumumab) and CD22 (inotuzumab), tyrosine kinase inhibitors targeting BCR-ABL1 tyrosine kinase, bispecific antibodies and chimeric antigen receptor T- cell therapy (CAR-T), circumvent B-ALL cell chemo-refractoriness through novel mechanisms of action, potentially eradicating minimal residual disease (MRD) and enabling more patients to receive allogeneic hematopoietic stem cell transplantation and to achieve a better clinical outcome.
2020
Lanza, F., Maffini, E., Saraceni, F., Massari, E., Rondoni, M., Daghia, G., et al. (2020). New monoclonal antibodies and tyrosine kinase inhibitors in B-cell acute lymphoblastic leukemia. MINERVA MEDICA, 111(5), 478-490 [10.23736/S0026-4806.20.07031-7].
Lanza, Francesco; Maffini, Enrico; Saraceni, Francesco; Massari, Evita; Rondoni, Michela; Daghia, Giulia; Olivieri, Attilio; Cerchione, Claudio; Marti...espandi
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/917956
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact