Some new dimefline‐type derivatives have been synthesized and their pharmacological activity, as well as their distribution coefficients have been determined. The distribution coefficients of a number of previously published analogue compounds have also been measured and the QSAR analysis of the whole set has been carried out. The results of such analysis allow to point out which factors are influencing the biological activity of this group of compounds. Copyright © 1989 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Synthesis and Quantitative Structure‐Activity Relationships of Analeptic Agents Related to Dimefline / Recanatini M.; Valenti P.; Re P.D.; Giusti P.. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - STAMPA. - 322:5(1989), pp. 257-261. [10.1002/ardp.19893220504]
Synthesis and Quantitative Structure‐Activity Relationships of Analeptic Agents Related to Dimefline
Recanatini M.;Valenti P.;
1989
Abstract
Some new dimefline‐type derivatives have been synthesized and their pharmacological activity, as well as their distribution coefficients have been determined. The distribution coefficients of a number of previously published analogue compounds have also been measured and the QSAR analysis of the whole set has been carried out. The results of such analysis allow to point out which factors are influencing the biological activity of this group of compounds. Copyright © 1989 WILEY‐VCH Verlag GmbH & Co. KGaA, WeinheimI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
