The log k’ values of a series of xanthine and adenosine derivatives were measured by means of a reversed-phase HPLC. The HPLC data were shown to be well correlated with previously reported RH and RMC18 values. The equations describing the relationships log k/rm and log k'/RHC18 allowed the calculation of the log k’ values of some compounds, which were not tested in the HPLC system. Since the relationship log k'/log P is very close to the previously described relationships RH /log P and RHC18/log P one can\conclude that reversed-phase TLC and HPLC are very similar in describing the lipophilicity of the compounds. © 1990, Taylor & Francis Group, LLC. All rights reserved.
Biagi G.L., Guerra M.C., Barbaro A.M., Barbieri S.B., Recanatini M., Borea P.A. (1990). Study of the lipophilic character of xanthine and adenosine derivatives. ii. relationships between log k’,rm and log p values. JOURNAL OF LIQUID CHROMATOGRAPHY, 13(5), 913-927 [10.1080/01483919008049221].
Study of the lipophilic character of xanthine and adenosine derivatives. ii. relationships between log k’,rm and log p values
Biagi G. L.;Guerra M. C.;Barbaro A. M.;Recanatini M.;
1990
Abstract
The log k’ values of a series of xanthine and adenosine derivatives were measured by means of a reversed-phase HPLC. The HPLC data were shown to be well correlated with previously reported RH and RMC18 values. The equations describing the relationships log k/rm and log k'/RHC18 allowed the calculation of the log k’ values of some compounds, which were not tested in the HPLC system. Since the relationship log k'/log P is very close to the previously described relationships RH /log P and RHC18/log P one can\conclude that reversed-phase TLC and HPLC are very similar in describing the lipophilicity of the compounds. © 1990, Taylor & Francis Group, LLC. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
