The RM values of a series of xanthine and adenosine derivatives were measured using silicone reversed-phase thin-layer chromatographic (TLC) and C18 reversed-phase high-performance TLC systems. The two series of data were well correlated. Both were compared with experimental log P and calculated CLOGP values. For xanthine derivatives a good linear relationship was shown between the RM values from the two chromatographic systems and the log P or CLOGP data. For adenosine derivatives the CLOGP values had to be corrected in order to fit the data to the same equation. The TLC data proved to be reliable parameters for describing the lipophilic properties of the test compounds. © 1990.

Study of the lipophilic character of xanthine and adenosine derivatives. I. RM and log P values / Biagi G.L.; Guerra M.C.; Barbaro A.M.; Barbieri S.; Recanatini M.; Borea P.A.; Pietrogrande M.C.. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 1873-3778. - STAMPA. - 498:C(1990), pp. 179-190. [10.1016/S0021-9673(01)84246-1]

Study of the lipophilic character of xanthine and adenosine derivatives. I. RM and log P values

Biagi G. L.;Guerra M. C.;Barbaro A. M.;Recanatini M.;
1990

Abstract

The RM values of a series of xanthine and adenosine derivatives were measured using silicone reversed-phase thin-layer chromatographic (TLC) and C18 reversed-phase high-performance TLC systems. The two series of data were well correlated. Both were compared with experimental log P and calculated CLOGP values. For xanthine derivatives a good linear relationship was shown between the RM values from the two chromatographic systems and the log P or CLOGP data. For adenosine derivatives the CLOGP values had to be corrected in order to fit the data to the same equation. The TLC data proved to be reliable parameters for describing the lipophilic properties of the test compounds. © 1990.
1990
Study of the lipophilic character of xanthine and adenosine derivatives. I. RM and log P values / Biagi G.L.; Guerra M.C.; Barbaro A.M.; Barbieri S.; Recanatini M.; Borea P.A.; Pietrogrande M.C.. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 1873-3778. - STAMPA. - 498:C(1990), pp. 179-190. [10.1016/S0021-9673(01)84246-1]
Biagi G.L.; Guerra M.C.; Barbaro A.M.; Barbieri S.; Recanatini M.; Borea P.A.; Pietrogrande M.C.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/916965
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 42
  • ???jsp.display-item.citation.isi??? 42
social impact