The RM for a new series of cardiac glycosides were calculated by means of some of the ΔRM, values previously derived from another series of compounds. The experimental or calculated RM values of both series of derivatives were correlated with the acute toxicity data (log 1/C). The slopes of the linear equations for cats, dogs, guinea-pigs and frogs are very close, showing that the dependence of toxicity on the lipophilic character is the same in these animal species. © 1991.
Biagi G.L., Guerra M.C., Barbaro A.M., Sapone A., Recanatini M. (1991). Lipophilic character of cardiac glycosides: correlation between RM values and acute toxicity data in different animal species. JOURNAL OF CHROMATOGRAPHY A, 547(C), 523-530 [10.1016/S0021-9673(01)88683-0].
Lipophilic character of cardiac glycosides: correlation between RM values and acute toxicity data in different animal species
Biagi G. L.;Guerra M. C.;Barbaro A. M.;Sapone A.;Recanatini M.
1991
Abstract
The RM for a new series of cardiac glycosides were calculated by means of some of the ΔRM, values previously derived from another series of compounds. The experimental or calculated RM values of both series of derivatives were correlated with the acute toxicity data (log 1/C). The slopes of the linear equations for cats, dogs, guinea-pigs and frogs are very close, showing that the dependence of toxicity on the lipophilic character is the same in these animal species. © 1991.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
