Chromatographic RM values were measured for a series of 41 cardiac glycosides and aglycones. By means of the ΔRM values it was possible to calculate the RM values for a further 19 compounds. An excellent correlation was found between the present RM values and those measured or calculated with the Cohnen et al. system. In a similar way, the RM values were shown to be well correlated with both high-performance liquid chromatographic data octanol-water partition coefficients (log P). The additive contribution of each substituent group to the overall lipophilicity of the molecule seems to be constant in each subset of Digitalis derivatives. © 1990.
Biagi G.L., Barbaro A.M., Guerra M.C., Borea P.A., Recanatini M. (1990). Lipophilic character of cardiac glycosides. RM values as lipophilicity parameters. JOURNAL OF CHROMATOGRAPHY A, 504(C), 163-178 [10.1016/S0021-9673(01)89522-4].
Lipophilic character of cardiac glycosides. RM values as lipophilicity parameters
Biagi G. L.;Barbaro A. M.;Guerra M. C.;Recanatini M.
1990
Abstract
Chromatographic RM values were measured for a series of 41 cardiac glycosides and aglycones. By means of the ΔRM values it was possible to calculate the RM values for a further 19 compounds. An excellent correlation was found between the present RM values and those measured or calculated with the Cohnen et al. system. In a similar way, the RM values were shown to be well correlated with both high-performance liquid chromatographic data octanol-water partition coefficients (log P). The additive contribution of each substituent group to the overall lipophilicity of the molecule seems to be constant in each subset of Digitalis derivatives. © 1990.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
