Chromatographic RM values were measured for a series of 41 cardiac glycosides and aglycones. By means of the ΔRM values it was possible to calculate the RM values for a further 19 compounds. An excellent correlation was found between the present RM values and those measured or calculated with the Cohnen et al. system. In a similar way, the RM values were shown to be well correlated with both high-performance liquid chromatographic data octanol-water partition coefficients (log P). The additive contribution of each substituent group to the overall lipophilicity of the molecule seems to be constant in each subset of Digitalis derivatives. © 1990.

Lipophilic character of cardiac glycosides. RM values as lipophilicity parameters / Biagi G.L.; Barbaro A.M.; Guerra M.C.; Borea P.A.; Recanatini M.. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 1873-3778. - STAMPA. - 504:C(1990), pp. 163-178. [10.1016/S0021-9673(01)89522-4]

Lipophilic character of cardiac glycosides. RM values as lipophilicity parameters

Biagi G. L.;Barbaro A. M.;Guerra M. C.;Recanatini M.
1990

Abstract

Chromatographic RM values were measured for a series of 41 cardiac glycosides and aglycones. By means of the ΔRM values it was possible to calculate the RM values for a further 19 compounds. An excellent correlation was found between the present RM values and those measured or calculated with the Cohnen et al. system. In a similar way, the RM values were shown to be well correlated with both high-performance liquid chromatographic data octanol-water partition coefficients (log P). The additive contribution of each substituent group to the overall lipophilicity of the molecule seems to be constant in each subset of Digitalis derivatives. © 1990.
1990
Lipophilic character of cardiac glycosides. RM values as lipophilicity parameters / Biagi G.L.; Barbaro A.M.; Guerra M.C.; Borea P.A.; Recanatini M.. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 1873-3778. - STAMPA. - 504:C(1990), pp. 163-178. [10.1016/S0021-9673(01)89522-4]
Biagi G.L.; Barbaro A.M.; Guerra M.C.; Borea P.A.; Recanatini M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/916941
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