Quantitative structure-activity relationships have been formulated for four sets of amidine inhibitors of trypsin. The quantitative results from these equations are compared with qualitative models constructed from the X-ray crystallographic coordinates of a benzamidine bound to trypsin. The good agreement between the mathematical and graphics models provides further support for the use of substituent constants and regression analysis in the study of enzyme-ligand interactions.
Quantitative structure-activity relationships and molecular graphics in ligand receptor interactions: Amidine inhibition of trypsin / Recanatini M.; Klein T.; Yang C.Z.; McClarin J.; Langridge R.; Hansch C.. - In: MOLECULAR PHARMACOLOGY. - ISSN 0026-895X. - STAMPA. - 29:4(1986), pp. 436-446.
Quantitative structure-activity relationships and molecular graphics in ligand receptor interactions: Amidine inhibition of trypsin
Recanatini M.;
1986
Abstract
Quantitative structure-activity relationships have been formulated for four sets of amidine inhibitors of trypsin. The quantitative results from these equations are compared with qualitative models constructed from the X-ray crystallographic coordinates of a benzamidine bound to trypsin. The good agreement between the mathematical and graphics models provides further support for the use of substituent constants and regression analysis in the study of enzyme-ligand interactions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.