The asymmetric 1,4 addition of PhMgCl, MeMgBr and allylMgBr to chiral imides 1 has been studied under various conditions. The presence of a Lewis acid, as AlMe2Cl, affords an enhanced diastereoselectivity favouring the formation of the product derived from the attack on the re face. The 1,4 addition of allyl diisopropoxyborate to imides 1 has also been analysed. Copyright © 1996 Elsevier Science Ltd.
Bongini A., Cardillo G., Mingardi A., Tomasini C. (1996). Asymmetric 1,4 addition of grignard reagents to chiral α,β-unsaturated imides in the presence of Lewis acids. TETRAHEDRON-ASYMMETRY, 7(5), 1457-1466 [10.1016/0957-4166(96)00163-2].
Asymmetric 1,4 addition of grignard reagents to chiral α,β-unsaturated imides in the presence of Lewis acids
Bongini A.;Mingardi A.;Tomasini C.
1996
Abstract
The asymmetric 1,4 addition of PhMgCl, MeMgBr and allylMgBr to chiral imides 1 has been studied under various conditions. The presence of a Lewis acid, as AlMe2Cl, affords an enhanced diastereoselectivity favouring the formation of the product derived from the attack on the re face. The 1,4 addition of allyl diisopropoxyborate to imides 1 has also been analysed. Copyright © 1996 Elsevier Science Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
