The asymmetric 1,4 addition of PhMgCl, MeMgBr and allylMgBr to chiral imides 1 has been studied under various conditions. The presence of a Lewis acid, as AlMe2Cl, affords an enhanced diastereoselectivity favouring the formation of the product derived from the attack on the re face. The 1,4 addition of allyl diisopropoxyborate to imides 1 has also been analysed. Copyright © 1996 Elsevier Science Ltd.
Asymmetric 1,4 addition of grignard reagents to chiral α,β-unsaturated imides in the presence of Lewis acids
Bongini A.;Mingardi A.;Tomasini C.
1996
Abstract
The asymmetric 1,4 addition of PhMgCl, MeMgBr and allylMgBr to chiral imides 1 has been studied under various conditions. The presence of a Lewis acid, as AlMe2Cl, affords an enhanced diastereoselectivity favouring the formation of the product derived from the attack on the re face. The 1,4 addition of allyl diisopropoxyborate to imides 1 has also been analysed. Copyright © 1996 Elsevier Science Ltd.File in questo prodotto:
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