The deconjugation of α,β-unsaturated acid chlorides in the presence of triethylamine and benzyl alcohol in CH 2 Cl 2 affords the corresponding β,γ-unsaturated benzylic esters in high yield and under mild conditions. Moreover by treatment of benzyl 2-bromo-3-methyl-3-butenoate 8 with benzylamine in the presence of trimethylamine, the corresponding benzyl 2-benzylamino-3-methyl-3-butenoate 9 is obtained in good yield.
Synthesis of β,γ-Unsaturated Esters from α,β-Unsaturated Acid Chlorides / Cardillo G.; De Simone A.; Mingardi A.; Tomasini C.. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - 1995:11(1995), pp. 1131-1132. [10.1055/s-1995-5199]
Synthesis of β,γ-Unsaturated Esters from α,β-Unsaturated Acid Chlorides
Mingardi A.Investigation
;Tomasini C.Ultimo
Writing – Original Draft Preparation
1995
Abstract
The deconjugation of α,β-unsaturated acid chlorides in the presence of triethylamine and benzyl alcohol in CH 2 Cl 2 affords the corresponding β,γ-unsaturated benzylic esters in high yield and under mild conditions. Moreover by treatment of benzyl 2-bromo-3-methyl-3-butenoate 8 with benzylamine in the presence of trimethylamine, the corresponding benzyl 2-benzylamino-3-methyl-3-butenoate 9 is obtained in good yield.File in questo prodotto:
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