Abstract: The effects of interferon (IFN) alpha‐2a treatment on platelet function were evaluated in 20 patients affected by essential thrombo‐cythaemia (ET). Baseline data documented the well‐known abnormalities of in vitro platelet aggregation and the constant presence of a Δ‐storage pool deficiency. The therapy in all patients reduced the platelet count, and in the majority of them caused a partial improvement of in vitro platelet aggregation. Although the mean intraplatelet ADP level improved during treatment, it always remained below the normal range documenting persistence of the Δ‐storage pool deficiency. The plasma β‐TG levels, which initially were high, significantly decreased during treatment, but the β‐TG ratio and the platelet β‐TG values always remained within the normal range ‐ this suggests an absence of platelet activation either before or during therapy. Our results demonstrate that, despite significantly reducing the platelet count, IFN alpha‐2a treatment only partially corrects the qualitative platelet abnormalities in ET. © Munksgaard 1991
Platelet function and interferon alpha‐2a treatment in essential thrombocythaemia / Catani L.; Gugliotta L.; Cascione M.L.; Belmonte M.M.; Vianelli N.; Belardinelli A.R.; Tura S.. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - STAMPA. - 46:3(1991), pp. 158-162. [10.1111/j.1600-0609.1991.tb01270.x]
Platelet function and interferon alpha‐2a treatment in essential thrombocythaemia
Catani L.;
1991
Abstract
Abstract: The effects of interferon (IFN) alpha‐2a treatment on platelet function were evaluated in 20 patients affected by essential thrombo‐cythaemia (ET). Baseline data documented the well‐known abnormalities of in vitro platelet aggregation and the constant presence of a Δ‐storage pool deficiency. The therapy in all patients reduced the platelet count, and in the majority of them caused a partial improvement of in vitro platelet aggregation. Although the mean intraplatelet ADP level improved during treatment, it always remained below the normal range documenting persistence of the Δ‐storage pool deficiency. The plasma β‐TG levels, which initially were high, significantly decreased during treatment, but the β‐TG ratio and the platelet β‐TG values always remained within the normal range ‐ this suggests an absence of platelet activation either before or during therapy. Our results demonstrate that, despite significantly reducing the platelet count, IFN alpha‐2a treatment only partially corrects the qualitative platelet abnormalities in ET. © Munksgaard 1991I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
