Megakaryocyte developmentin vitro requires the presence of at least two overlapping regulatory activities: a colony stimulating activity which promotes cellular proliferation and limited maturation and a second co-regulator which directs maturational development. Since the responding meg cell populations represent a con- tinuous spectrum of differentiating cell phenotypes, factor responsivenessclearly overlaps. These two rather distinct processes as well as their complex regulation will be discussed in the first section of this review dealing with the biology of megakaryocytopoiesis . In the second part of this review we will consider a number of megakaryocytic disorders, comprising reactive and neoplastic diseases, which have been primarily characterized in the past by bone marrow histopathology.
Human megakaryocyte biology and pathophysiology / Zauli G.; Catani L.. - In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. - ISSN 1040-8428. - STAMPA. - 21:1-3(1995), pp. 135-157. [10.1016/1040-8428(94)00171-5]
Human megakaryocyte biology and pathophysiology
Catani L.
1995
Abstract
Megakaryocyte developmentin vitro requires the presence of at least two overlapping regulatory activities: a colony stimulating activity which promotes cellular proliferation and limited maturation and a second co-regulator which directs maturational development. Since the responding meg cell populations represent a con- tinuous spectrum of differentiating cell phenotypes, factor responsivenessclearly overlaps. These two rather distinct processes as well as their complex regulation will be discussed in the first section of this review dealing with the biology of megakaryocytopoiesis . In the second part of this review we will consider a number of megakaryocytic disorders, comprising reactive and neoplastic diseases, which have been primarily characterized in the past by bone marrow histopathology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
