Conditioned medium from a T-lymphoblastic cell line (Mo) contains a number of well characterized hemopoietins. In this paper we demonstrate that Mo cells also release a factor(s) able to stimulate the growth and the differentiation of megakaryocytic progenitors into large-size pure megakaryocytic colonies in plasma clot cultures. Comparison with other sources of human-active hemopoietins shows that Mo-conditioned medium performs better than others, especially for the megakaryocytic lineage. The factor(s) shows strong similarities with human Meg-CSF obtained from a thrombocytopenic patient's plasma, and is distinguishable from the other hemopoietins present in the medium.
Bagnara, G.P., Guarini, A., Gaggioli, L., Zauli, G., Catani, L., Valvassori, L., et al. (1987). Human T-lymphocyte-derived megakaryocyte colony-stimulating activity. EXPERIMENTAL HEMATOLOGY, 15(6), 679-684.
Human T-lymphocyte-derived megakaryocyte colony-stimulating activity
Bagnara G. P.
;Catani L.;Valvassori L.;
1987
Abstract
Conditioned medium from a T-lymphoblastic cell line (Mo) contains a number of well characterized hemopoietins. In this paper we demonstrate that Mo cells also release a factor(s) able to stimulate the growth and the differentiation of megakaryocytic progenitors into large-size pure megakaryocytic colonies in plasma clot cultures. Comparison with other sources of human-active hemopoietins shows that Mo-conditioned medium performs better than others, especially for the megakaryocytic lineage. The factor(s) shows strong similarities with human Meg-CSF obtained from a thrombocytopenic patient's plasma, and is distinguishable from the other hemopoietins present in the medium.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
