Conditioned medium from a T-lymphoblastic cell line (Mo) contains a number of well characterized hemopoietins. In this paper we demonstrate that Mo cells also release a factor(s) able to stimulate the growth and the differentiation of megakaryocytic progenitors into large-size pure megakaryocytic colonies in plasma clot cultures. Comparison with other sources of human-active hemopoietins shows that Mo-conditioned medium performs better than others, especially for the megakaryocytic lineage. The factor(s) shows strong similarities with human Meg-CSF obtained from a thrombocytopenic patient's plasma, and is distinguishable from the other hemopoietins present in the medium.
Human T-lymphocyte-derived megakaryocyte colony-stimulating activity / Bagnara G.P.; Guarini A.; Gaggioli L.; Zauli G.; Catani L.; Valvassori L.; Zunica G.; Gugliotta L.; Marini M.. - In: EXPERIMENTAL HEMATOLOGY. - ISSN 0301-472X. - STAMPA. - 15:6(1987), pp. 679-684.
Human T-lymphocyte-derived megakaryocyte colony-stimulating activity
Bagnara G. P.;Guarini A.;Zauli G.;Catani L.;Valvassori L.;
1987
Abstract
Conditioned medium from a T-lymphoblastic cell line (Mo) contains a number of well characterized hemopoietins. In this paper we demonstrate that Mo cells also release a factor(s) able to stimulate the growth and the differentiation of megakaryocytic progenitors into large-size pure megakaryocytic colonies in plasma clot cultures. Comparison with other sources of human-active hemopoietins shows that Mo-conditioned medium performs better than others, especially for the megakaryocytic lineage. The factor(s) shows strong similarities with human Meg-CSF obtained from a thrombocytopenic patient's plasma, and is distinguishable from the other hemopoietins present in the medium.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
