Complex traits are difficult to disentangle, as the phenotypes result from the interaction of different basic components where genetics interacts with environment, epigenetics and stochasticity (Cevenini et al., 2008). Studies in humans represent a particular challenge, owing to the pervasive and profound influence of cultural habits and specific evolutionary history on the different human populations. We will discuss the importance of adopting an integrated and multidisciplinary approach in genetic studies on two complex traits, such as aging and Chagas disease, as the most appropriate and correct methodology of data collection and analysis.

Genetics and anthropology in studies on aging and Chagas disease

FRANCESCHI, CLAUDIO;YANG YAO, DANIELE;SEVINI, FEDERICA;SANTORO, AURELIA;LUISELLI, DONATA;PETTENER, DAVIDE;CIANNAMEO, ANNA;FRANCESCHI, ZELDA ALICE
2010

Abstract

Complex traits are difficult to disentangle, as the phenotypes result from the interaction of different basic components where genetics interacts with environment, epigenetics and stochasticity (Cevenini et al., 2008). Studies in humans represent a particular challenge, owing to the pervasive and profound influence of cultural habits and specific evolutionary history on the different human populations. We will discuss the importance of adopting an integrated and multidisciplinary approach in genetic studies on two complex traits, such as aging and Chagas disease, as the most appropriate and correct methodology of data collection and analysis.
Claudio Franceschi; Daniele Yang Yao; Federica Sevini; Aurelia Santoro; Donata Luiselli; Davide Pettener; G.Ferri; Maria Cristina Dasso; Ricardo Perez de la Hoz; Edgardo Moretti; Beatriz Basso; Irma Castro; Anna Ciannameo; Zelda Alice Franceschi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/91479
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